The development of the mature mammalian kidney begins with the invasion of metanephric
mesenchyme by ureteric bud. Mesenchymal cells near the bud become induced and convert …

Although it is not easy to investigate the regulatory basis of developmental processes in
most mammalian tissues, the mouse kidney has several distinct advantages as a model …

Development of an organ is directed by cell and tissue interactions and these also occur
during the formation of functional kidney. During vertebrate development inductive signalling …

The molecular regulation of the complex inductive events associated with formation of the
vertebrate excretory system has been progressively elucidated as a result of both genetic …

Publisher Summary This chapter describes the earlier stages of development of the
vertebrate metanephric kidney. It focuses on the mouse and descriptive morphology is used …

Organogenesis of the kidney has been intensely studied for over a century. In recent years
advances in molecular techniques have not only made great inroads into exploring the …

Mammalian kidney development has helped elucidate the general concepts of
mesenchymal-epithelial interactions, inductive signaling, epithelial cell polarization, and …

The mammalian kidney consists of highly specialised cells that function in an integrated
manner to maintain homeostasis of body fluids, electrolytes and nutrients. Formation of …

The mammalian kidney may well be one of the most complex organs of postnatal life. Each
adult human kidney contains on average more than one million functional filtration units, the …

An understanding of the normal development of the urogenital tract, at both the structural
and molecular level, gives an insight into the mechanisms involved in renal pathology. In …