Bone is a dynamic tissue that adjusts its structure over time to adapt to changes in
mechanical load. This adaptive ability is critical to skeletal development and maintenance of …

Bone adapts readily and rapidly to its mechanical loading environment to give rise to a
functionally well designed tissue and organ. The “mechanosensor” for bone adaptation is …

Human body is subject to many and variegated mechanical stimuli, actuated in different
ranges of force, frequency, and duration. The process through which cells “feel” forces and …

Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the
increase in bone formation following the addition of exogenous loads and loss of bone mass …

Osteocytes are the major bone cell composing over 90-95% of all adult bone cells. These
cells with their long dendritic processes, their connectivity and strategically placed locations …

Mechanotransduction plays a crucial role in the physiology of many tissues including bone.
Mechanical loading can inhibit bone resorption and increase bone formation in vivo. In …

Mechanical force plays an important role in the regulation of bone remodelling in intact bone
and bone repair. In vitro, bone cells demonstrate a high responsiveness to mechanical …

Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment.
Increases in strain lead to increased bone mass acquisition, whereas decreases in strain …

Skeletal tissue is a reservoir of calcium that is important for proper muscle and nerve
function, and houses the marrow that supports the hematopoietic and mesenchymal stem …

This chapter reviews the state of knowledge with respect to skeletal mechanobiology. Forms
of tissue-level mechanical stimulation are first described, including electromagnetic fields …