[HTML][HTML] Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
Population-based biobanks with genomic and dense phenotype data provide opportunities
for generating effective therapeutic hypotheses and understanding the genomic role in …
for generating effective therapeutic hypotheses and understanding the genomic role in …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development and clinical guidelines. However, the …
the biology of complex traits, drug development and clinical guidelines. However, the …
Gene regulatory mechanisms underpinning prostate cancer susceptibility
T Whitington, P Gao, W Song, H Ross-Adams… - Nature …, 2016 - nature.com
Molecular characterization of genome-wide association study (GWAS) loci can uncover key
genes and biological mechanisms underpinning complex traits and diseases. Here we …
genes and biological mechanisms underpinning complex traits and diseases. Here we …
Genome-wide genetic data on~ 500,000 UK Biobank participants
C Bycroft, C Freeman, D Petkova, G Band, LT Elliott… - BioRxiv, 2017 - biorxiv.org
The UK Biobank project is a large prospective cohort study of~ 500,000 individuals from
across the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic …
across the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic …
[HTML][HTML] A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci
AC Joslin, DR Sobreira, GT Hansen, NJ Sakabe… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) have identified many disease-associated
variants, yet mechanisms underlying these associations remain unclear. To understand …
variants, yet mechanisms underlying these associations remain unclear. To understand …
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
Candidate gene and genome-wide association studies (GWAS) have identified genetic
variants that modulate risk for human disease; many of these associations require further …
variants that modulate risk for human disease; many of these associations require further …
Linking disease associations with regulatory information in the human genome
Genome-wide association studies have been successful in identifying single nucleotide
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
polymorphisms (SNPs) associated with a large number of phenotypes. However, an …
Bioinformatics challenges in genome-wide association studies (GWAS)
Genome-wide association studies (GWAS) are a powerful tool for investigators to examine
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …
[HTML][HTML] GWAS and drug targets
C Cao, J Moult - BMC genomics, 2014 - Springer
Background Genome wide association studies (GWAS) have revealed a large number of
links between genome variation and complex disease. Among other benefits, it is expected …
links between genome variation and complex disease. Among other benefits, it is expected …
Mining the unknown: assigning function to noncoding single nucleotide polymorphisms
SS Nishizaki, AP Boyle - Trends in Genetics, 2017 - cell.com
One of the formative goals of genetics research is to understand how genetic variation leads
to phenotypic differences and human disease. Genome-wide association studies (GWASs) …
to phenotypic differences and human disease. Genome-wide association studies (GWASs) …