Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
Thinking about the evolution of complex traits in the era of genome-wide association studies
Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
the variation they exhibit arises from differences at numerous loci in the genome. Complex …
[PDF][PDF] PheWAS and beyond: the landscape of associations with medical diagnoses and clinical measures across 38,662 individuals from Geisinger
Most phenome-wide association studies (PheWASs) to date have used a small to moderate
number of SNPs for association with phenotypic data. We performed a large-scale single …
number of SNPs for association with phenotypic data. We performed a large-scale single …