Transporter associated with Ag processing 1 and low molecular mass polypeptide 2 (LMP2)
are essential for class I MHC function and share a common bidirectional promoter. In murine …

The genes of the transporter associated with antigen processing (Tap)-1, and the low
molecular weight peptide (Lmp)-2, are crucial for class I major histocompatibility complex …

Although interferon-γ (IFN-γ) induces the transporter associated with antigen processing
(Tap)-1 expression in macrophages, cooperation with lipopolysaccharide signaling through …

The components of the antigen processing machinery, low molecular mass polypeptide
(LMP) 2 and transporter associated with antigen processing (TAP) 1, are encoded by closely …

Abstract Class I MHC complexes (MHC I) are essential in mediating immune response. The
transport of antigenic peptides (TAP) to MHC I and the stable expression of MHC I on the cell …

Objective: Using microarray technique we analysed global changes in gene expression of
interferon-γ treated primary macrophages. Among the differential expressed genes identified …

Expression of cell surface MHC class I: peptide complex requires coordinated expression of
multiple genes such as MHC class I heavy chain, β2-microglobulin (β2m), transporters …

Proper regulation of the Tap-1 gene is critical for the initiation and continuation of a cellular
immune response. Analysis of the Tap-1/low molecular mass polypeptide 2 bidirectional …

Cross-presentation is thought to require transport of proteasome-generated peptides by the
TAP transporters into MHC class I loading compartments for most antigens. However, a …

Transporter associated with antigen processing 2 (Tap-2) is responsible for ATP-dependent
transport of peptides from the cytosol to the endoplasmic reticulum, where peptides bind to …