The present study was designed to determine the molecular mechanisms by which
interleukin (IL)‐10 prevents the HLA class I antigen expression at the cell surface. In this …

Within the adaptive immune system the transporter associated with antigen processing
(TAP) plays a pivotal role in loading of peptides onto major histocompatibility (MHC) class I …

The Toll-like receptors (TLRs) play a pivotal role in innate immunity for the detection of
highly conserved, pathogen-expressed molecules. Previously, we demonstrated that …

Influenza A virus (IAV) infection causes significant morbidity and mortality worldwide. Matrix
metalloproteinase-9 (MMP-9) degrades extracellular matrix and is involved in the pathology …

Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a
proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune …

Mice deficient in the gene encoding the transporter associated with antigen processing 1
(TAP1) are defective in providing major histocompatibility complex (MHC) class I molecules …

It is demonstrated that similar to interferon γ (IFN-γ), tumor necrosis factor-α (TNF-α) induces
coordinated changes at different steps of the major histocompatibility complex (MHC) class I …

Presentation of intracellularly derived antigenic peptides to T cells requires their assembly
together with MHC class I molecules in the endoplasmic reticulum (ER). Such peptides are …

Effective major histocompatibility complex-II (MHC-II) antigen presentation from
phagocytosed particles requires phagosome-intrinsic Toll-like receptor (TLR) signaling, but …

Presentation of peptides derived from cytosolic and nuclear proteins by MHC class I
molecules requires their translocation across the membrane of the endoplasmic reticulum …