Assembly and cell surface expression of TAP-independent, chloroquine-sensitive and interferon-γ-inducible class I MHC complexes in transformed fibroblast cell lines …
SV Fromm, SDB Yaakov, C Schechter, R Ehrlich - Cellular immunology, 2002 - Elsevier
Antigen processing and presentation by class I MHC molecules generally require assembly
with peptide epitopes generated by the proteasome and transported into the ER by the …
with peptide epitopes generated by the proteasome and transported into the ER by the …
[HTML][HTML] Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage
F Song, Y Yi, C Li, Y Hu, J Wang, DE Smith… - Cell death & …, 2018 - nature.com
The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain
dipeptide and peptidomimetics from inside the lysosome to cytosol. Previous studies have …
dipeptide and peptidomimetics from inside the lysosome to cytosol. Previous studies have …
Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and-independent manner
R Zeng, Y Aoki, M Yoshida, K Arai… - The Journal of …, 2002 - journals.aai.org
In response to cytokine stimuli, Stats are phosphorylated and translocated to the nucleus to
activate target genes. Then, most are dephosphorylated and returned to the cytoplasm …
activate target genes. Then, most are dephosphorylated and returned to the cytoplasm …
[HTML][HTML] Using the TAP component of the antigen-processing machinery as a molecular adjuvant
TZ Vitalis, QJ Zhang, J Alimonti, SS Chen… - PLoS …, 2005 - journals.plos.org
We hypothesize that over-expression of transporters associated with antigen processing
(TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I …
(TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I …
Nramp1 transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on antigen processing and presentation
T Lang, E Prina, D Sibthorpe… - Infection and …, 1997 - Am Soc Microbiol
The natural resistance-associated macrophage protein (Nramp1) regulates macrophage
activation. One of its pleiotropic effects on macrophage function is to regulate expression of …
activation. One of its pleiotropic effects on macrophage function is to regulate expression of …
[PDF][PDF] Lipopolysaccharide could be internalized into human peripheral blood mononuclear cells and elicit TNF-alpha release, but not via the pathway of toll-like …
H Zhou, G Ding, W Liu, L Wang, Y Lu, H Cao… - Cell Mol …, 2004 - researchgate.net
Lipopolysaccharide (LPS), the principal component of the outer membrane of gram-negative
bacteria, stimulate various cell types to release numerous proinflammatory mediators such …
bacteria, stimulate various cell types to release numerous proinflammatory mediators such …
[HTML][HTML] LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes
C Sibille, KG Gould, K Willard-Gallo, S Thomson… - Current Biology, 1995 - cell.com
Background: Major histocompatibility complex (MHC) class I molecules present short
peptides generated by intracellular protein degradation to cytotoxic T lymphocytes (CTL) …
peptides generated by intracellular protein degradation to cytotoxic T lymphocytes (CTL) …
Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1
U Ritz, I Drexler, D Sutter, R Abele, C Huber… - The Journal of …, 2003 - journals.aai.org
The heterodimeric peptide transporter TAP belongs to the ABC transporter family. Sequence
comparisons with the P-glycoprotein and cystic fibrosis transmembrane conductance …
comparisons with the P-glycoprotein and cystic fibrosis transmembrane conductance …
[HTML][HTML] Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages
SH Rhee, BW Jones, V Toshchakov, SN Vogel… - Journal of Biological …, 2003 - ASBMB
Engagement of Toll-like receptor (TLR) proteins activates multiple signal transduction
pathways. These studies show that engagement of TLR2 and TLR4 leads to rapid …
pathways. These studies show that engagement of TLR2 and TLR4 leads to rapid …
[HTML][HTML] The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for Toll-like receptor 2
K Kurokawa, H Lee, KB Roh, M Asanuma… - Journal of Biological …, 2009 - ASBMB
Some synthetic lipopeptides, in addition to native lipoproteins derived from both Gram-
negative bacteria and mycoplasmas, are known to activate TLR2 (Toll-like receptor 2) …
negative bacteria and mycoplasmas, are known to activate TLR2 (Toll-like receptor 2) …