The transporter associated with antigen presentation (TAP) complex shuttles cytosolic
peptides into the exocytic compartment for association with nascent major histocompatibility …

Kenneth P. Zwicker (57) ABSTRACT Splice variants of known TAP1 and TAP2 proteins,
which are involved in translocation of antigen peptides into the endoplasmic reticulum for …

With recent studies suggesting a key role for professional antigen presenting cells in the
induction of major histocompatibility class I cellular immune responses, we initiated studies …

Tapasin is a member of the MHC class I loading complex where it bridges the TAP peptide
transporter to class I molecules. The main role of tapasin is assumed to be the facilitation of …

Antimicrobial effector proteins are a key mechanism for the innate immune system to combat
pathogens once they infect the host. We report the identification and cloning of the mouse …

Previous studies have shown that engagement of Toll-like receptors (TLR) 2 and 4 can
induce macrophages to express a variety of proinflammatory cytokines. We have recently …

The protein products of the Tap (Transporter associated with antigen processing) 1 and 2
genes are presumed to deliver peptides across the endoplasmic reticulum (ER) for …

The transporter associated with antigen processing (TAP) is a crucial element of the
adaptive immune system, which translocates proteasomal degradation products into the …

STAT1 has a key role in the regulation of innate and adaptive immunity by inducing
transcriptional changes in response to cytokines, such as all types of interferons (IFN) …

Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated
macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune …