Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
K Obata, H Yamanaka, Y Dai, T Mizushima, T Fukuoka… - Neuroscience, 2004 - Elsevier
Inflammation of the primary afferent proximal to the dorsal root ganglion (DRG) and the DRG
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats
K Obata, H Yamanaka, Y Dai… - European Journal of …, 2004 - Wiley Online Library
To investigate the intracellular signal transduction pathways involved in the
pathophysiological mechanisms of neuropathic pain after partial nerve injury, we examined …
pathophysiological mechanisms of neuropathic pain after partial nerve injury, we examined …
Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after …
K Obata, H Yamanaka, Y Dai, T Tachibana… - Journal of …, 2003 - Soc Neuroscience
To investigate the intracellular signal transduction pathways involved in regulating the gene
expression of brain-derived neurotrophic factor (BDNF) in primary afferent neurons, we …
expression of brain-derived neurotrophic factor (BDNF) in primary afferent neurons, we …
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitrostudy
YT Lin, LS Ro, HL Wang, JC Chen - Journal of neuroinflammation, 2011 - Springer
Background During inflammation, immune cells accumulate in damaged areas and release
pro-inflammatory cytokines and neurotrophins. Brain-derived neurotrophic factor (BDNF) …
pro-inflammatory cytokines and neurotrophins. Brain-derived neurotrophic factor (BDNF) …
Activation of p38 mitogen-activated protein kinase in the dorsal root ganglion contributes to pain hypersensitivity after plantar incision
K Mizukoshi, M Sasaki, Y Izumi, M Miura, M Watanabe… - Neuroscience, 2013 - Elsevier
BACKGROUND: The phosphorylation of p38 mitogen-activated protein kinase (MAPK) in the
dorsal root ganglion (DRG) promotes primary afferent sensitization. The role of p38MAPK …
dorsal root ganglion (DRG) promotes primary afferent sensitization. The role of p38MAPK …
Extracellular signal-regulated kinase mitogen-activated protein kinase activation in the dorsal root ganglion (DRG) and spinal cord after DRG injury in rats
H Doya, S Ohtori, K Takahashi, Y Aoki, H Ino… - Spine, 2005 - journals.lww.com
Study Design. We investigated the extracellular signal-regulated kinase (ERK) activation by
immunohistochemically detecting phosphorylated ERK (pERK) in the dorsal root ganglion …
immunohistochemically detecting phosphorylated ERK (pERK) in the dorsal root ganglion …
TNF-α and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica
N Takahashi, S Kikuchi, VI Shubayev, WM Campana… - Spine, 2006 - journals.lww.com
Study Design. Characterize extracellular signal-regulated kinase (ERK) and its
phosphorylation (pERK) in neural tissues after topical application of tumor necrosis factor …
phosphorylation (pERK) in neural tissues after topical application of tumor necrosis factor …
c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity
H Doya, S Ohtori, M Fujitani, T Saito, K Hata… - Biochemical and …, 2005 - Elsevier
Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …
The upregulation of EGFR in the dorsal root ganglion contributes to chronic compression of dorsal root ganglions-induced neuropathic pain in rats
S Wang, S Liu, L Xu, X Zhu, W Liu, L Tian… - Molecular …, 2019 - journals.sagepub.com
The epidermal growth factor receptor (EGFR) located in dorsal root ganglion has been found
as a new target for chronic pain treatment. However, it is not clear whether the change of …
as a new target for chronic pain treatment. However, it is not clear whether the change of …
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain …
Activation of ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein)
kinase in dorsal horn neurons of the spinal cord by peripheral noxious stimulation …
kinase in dorsal horn neurons of the spinal cord by peripheral noxious stimulation …
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