Transporter‐mediated drug–drug interactions are one of the major mechanisms in
pharmacokinetic‐based drug interactions and correspondingly affecting drugs' safety and …

Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …

Introduction: The key role of transporter biology in both the manifestation and treatment of
disease is now firmly established. Experiences of sub-optimal drug exposure due to drug …

Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

▪ Abstract Recent studies have revealed the import role played by transporters in the renal
and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate …

Objectives Membrane transporters and metabolism are major determinants of the
hepatobiliary elimination of drugs. This work investigates several key questions for drug …

The ability to predict hepatic metabolic clearance is a key component in the design and
selection of small molecule drug candidates within the pharmaceutical industry. The …

Drug–drug interactions mediated by transporters are a serious clinical concern hence a
tremendous amount of work has been done on the characterization of the transporter …

Background: Hepatic transporters, including efflux transporters and uptake transporters,
have been recognized to play an important role in the disposition of various drugs. These …

Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …