Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments

MK Gandhi, R Khanna - The Lancet infectious diseases, 2004 - thelancet.com
After initial infection, human cytomegalovirus remains in a persistent state with the host.
Immunity against the virus controls replication, although intermitent viral shedding can still …

Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation

PD Griffiths - The Lancet infectious diseases, 2012 - thelancet.com
Cytomegalovirus is the most frequent cause of intrauterine infection and the commonest
infectious agent to affect allograft recipients, yet the virus is acknowledged rarely as an …

Cytomegalovirus treatment

BH Tan - Current treatment options in infectious diseases, 2014 - Springer
Opinion statement In treating cytomegalovirus (CMV) infection, it is crucial to decide whether
one is treating pre-emptively or if one is treating established disease. Disease may be …

[PDF][PDF] Advances in the treatment of cytomegalovirus

BA Krishna, MR Wills, JH Sinclair - British Medical Bulletin, 2019 - academic.oup.com
Background Human cytomegalovirus (HCMV) is a threat to immunologically weak patients.
HCMV cannot yet be eliminated with a vaccine, despite recent advances. Sources of data …

The human cytomegalovirus

S Landolfo, M Gariglio, G Gribaudo, D Lembo - Pharmacology & …, 2003 - Elsevier
Human cytomegalovirus (HCMV), a betaherpesvirus, represents the major infectious cause
of birth defects, as well as an important pathogen for immunocompromised individuals. The …

Antiviral treatment of cytomegalovirus infection

A Ahmed - Infectious Disorders-Drug Targets (Formerly Current …, 2011 - ingentaconnect.com
Cytomegalovirus (CMV) is an opportunistic pathogen associated with significant morbidity
and mortality in immunocompromised hosts. Antiviral agents specifically targeting CMV were …

Immunobiology of human cytomegalovirus: from bench to bedside

T Crough, R Khanna - Clinical microbiology reviews, 2009 - Am Soc Microbiol
Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

The pathogenesis of human cytomegalovirus

P Griffiths, I Baraniak, M Reeves - The Journal of pathology, 2015 - Wiley Online Library
Human cytomegalovirus (HCMV) is a recognized cause of disease in the fetus, the allograft
recipient and AIDS patients. More recently, it has been recognized as a pathogen for those …

Cytomegalovirus: pathogen, paradigm, and puzzle

M Boeckh, AP Geballe - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Human cytomegalovirus (CMV), one of the eight herpesviruses that commonly infect
humans, is best known for its propensity to cause disease in immunocompromised patients …