Tumor heterogeneity is a major obstacle to the success of cancer treatment. An accurate
understanding and recognition of tumor heterogeneity is critical in the clinical management …

purpose. The liver is the most common site of systemic metastases from uveal melanoma
(UM). Such metastases usually continue to develop despite the application of current …

Uveal melanoma arises from melanocytes located in the uveal tract of the eye and is the
most common primary intraocular tumor in adults. Metastatic liver disease is the …

Background Uveal melanoma is an aggressive cancer which has a high percentage
metastasizing to the liver, with a worse prognosis. Identification of patients at high risk of …

Simple Summary Uveal melanoma (UM) is a rare aggressive eye cancer. Although
treatment of the eye tumour is successful, about 50% of UM patients develop a relapse of …

Purpose The purpose of this study was to correlate magnetic resonance imaging (MRI)
radiographic results with histopathologic growth patterns of metastatic uveal melanoma …

Intratumor heterogeneity has been recognized in numerous cancers as a major source of
metastatic dissemination. In uveal melanomas, the existence and identity of specific …

Importance To the best of my knowledge, this study demonstrates for the first time small,
apparently dormant micrometastasis in the liver of patients with uveal melanoma. Objective …

Simple Summary Malignant melanoma is a highly metastatic disease disseminating to
several distant sites. This potential is also of great clinical impact for patient survival and …

Background Metastasis is characterized by spreading of neoplastic cells to an organ other
than where they originated and is the predominant cause of death among cancer patients …