Aim: To investigate whether p38 small-interfering RNA-loaded nanoparticles (p38 siRNA
NPs) attenuate spinal nerve ligation (SNL)-induced neuropathic pain in rats by suppressing …

Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can
attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic …

Activation of CX3CR1 in microglia plays an important role in the development of neuropathic
pain. Here, we investigated whether neuropathic pain could be attenuated in spinal nerve …

p66shc, a member of the shc adaptor protein family, has been shown to participate in
regulation of mitochondrial homeostasis, apoptosis, and autophagosome formation. The …

Activation of nuclear factor-kappa B (NF-κB) in microglia plays a decisive role in the
progress of neuropathic pain, and the inhibitor of kappa B (IκB) is a protein that blocks the …

Microglia play a critical role in neuropathic pain. Since upregulated Foxp3 in microglia
enhances tissue repair by resolving neuroinflammation in excitotoxin-induced neuronal …

Chronic neuroinflammation is an important factor in the development of neuropathic pain
(NP). Excess microglia activation releases a mass of pro-inflammatory cytokines during …

Neuropathic pain (NP) is among the most intractable comorbidities of spinal cord injury.
Dysregulation of non-coding RNAs has also been implicated in the development of …

Abstract Double-stranded RNA (dsRNA)–activated kinase (PKR) is an important component
in inflammation and immune dysfunction. However, the role of PKR in neuropathic pain …

Duloxetine (DLX) is a selective serotonin and noradrenaline reuptake inhibitor (SNRI) used
for the treatment of pain, but it has been reported to show side effects in 10–20% of patients …