Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases.

R De Sire, G Rizzatti, F Ingravalle… - Minerva …, 2018 - europepmc.org
In recent years, there has been an increasing interest on muscle wasting, considering the
reduction of quality of life and the increase of morbidity and mortality associated. Sarcopenia …

A narrative review of gut-muscle axis and sarcopenia: The potential role of gut microbiota

J Zhao, Y Huang, X Yu - International Journal of General Medicine, 2021 - Taylor & Francis
Sarcopenia is a multifactorial disease related to aging, chronic inflammation, insufficient
nutrition, and physical inactivity. Previous studies have suggested that there is a relationship …

Inflammatory bowel diseases and sarcopenia: the role of inflammation and gut microbiota in the development of muscle failure

OM Nardone, R de Sire, V Petito, A Testa… - Frontiers in …, 2021 - frontiersin.org
Sarcopenia represents a major health burden in industrialized country by reducing
substantially the quality of life. Indeed, it is characterized by a progressive and generalized …

Sarcopenia is a cause and consequence of metabolic dysregulation in aging humans: effects of gut dysbiosis, glucose dysregulation, diet and lifestyle

JW Daily, S Park - Cells, 2022 - mdpi.com
Skeletal muscle mass plays a critical role in a healthy lifespan by helping to regulate
glucose homeostasis. As seen in sarcopenia, decreased skeletal muscle mass impairs …

Mechanisms linking the gut-muscle axis with muscle protein metabolism and anabolic resistance: implications for older adults at risk of sarcopenia

K Prokopidis, E Chambers, M Ni Lochlainn… - Frontiers in …, 2021 - frontiersin.org
Aging is associated with a decline in skeletal muscle mass and function—termed sarcopenia—
as mediated, in part, by muscle anabolic resistance. This metabolic phenomenon describes …

Gut dysbiosis and muscle aging: searching for novel targets against sarcopenia

A Picca, F Fanelli, R Calvani, G Mulè… - Mediators of …, 2018 - Wiley Online Library
Advanced age is characterized by several changes, one of which is the impairment of the
homeostasis of intestinal microbiota. These alterations critically influence host health and …

Muscle wasting: the gut microbiota as a new therapeutic target?

LB Bindels, NM Delzenne - The international journal of biochemistry & cell …, 2013 - Elsevier
Muscle wasting is characterized by a loss of muscle mass and strength, and occurs in
several pathological conditions such as cancer, chronic heart failure, chronic infection and …

Role of the gut microbiome in skeletal muscle physiology and pathophysiology

C Lefevre, LB Bindels - Current osteoporosis reports, 2022 - Springer
Abstract Purpose of Review This review aims to summarize the recent findings about the
contribution of the gut microbiome to muscle pathophysiology and discuss molecular …

[HTML][HTML] Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota

R Maslennikov, A Alieva, E Poluektova… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Decreased muscle mass and function, also known as sarcopenia, is common in patients
with cirrhosis and is associated with a poor prognosis. Although the pathogenesis of this …

Putting some muscle into sarcopenia—the pathogenesis, assessment and clinical impact of muscle loss in patients with inflammatory bowel disease

SL Gold, M Raman, BE Sands… - Alimentary …, 2023 - Wiley Online Library
Background Sarcopenia, a loss of skeletal muscle mass or function, affects up to 50% of
patients with inflammatory bowel disease (IBD) and is associated with poor clinical …