Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19

H Zhang, H Chen, J Zhang, X Chen… - … and Critical Care …, 2021 - journals.lww.com
Background: Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral
infection, without any available targeted therapies. The high mortality rate of COVID-19 is …

Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients

TA Taz, K Ahmed, BK Paul, FA Al-Zahrani… - Briefings in …, 2021 - academic.oup.com
This study aimed to identify significant gene expression profiles of the human lung epithelial
cells caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …

Molecular modeling of C1‐inhibitor as SARS‐CoV‐2 target identified from the immune signatures of multiple tissues: An integrated bioinformatics study

K Sekaran, R Polachirakkal Varghese… - Cell Biochemistry …, 2023 - Wiley Online Library
The expeditious transmission of the severe acute respiratory coronavirus 2 (SARS‐CoV‐2),
a strain of COVID‐19, crumbled the global economic strength and caused a veritable …

Explanatory predictive model for COVID-19 severity risk employing machine learning, shapley addition, and LIME

M Laatifi, S Douzi, H Ezzine, CE Asry, A Naya… - Scientific Reports, 2023 - nature.com
The rapid spread of SARS-CoV-2 threatens global public health and impedes the operation
of healthcare systems. Several studies have been conducted to confirm SARS-CoV-2 …

[HTML][HTML] Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity: in silico gene expression analysis

YH Wu, IJ Yeh, NN Phan, MC Yen, HL Liu… - … journal of medical …, 2021 - ncbi.nlm.nih.gov
Highly pathogenic coronaviruses (CoVs) induce acute respiratory distress syndrome, and
the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused a pandemic …

[HTML][HTML] COVID-19 and lung cancer: risks, mechanisms and treatment interactions

A Addeo, M Obeid, A Friedlaender - Journal for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Cases of the 2019 novel coronavirus also known as severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) continue to rise worldwide. To date, there is no effective …

Bioinformatics Approach Predicts Candidate Targets for SARS‐CoV‐2 Infections to COPD Patients

L Che, G Chen, X Cai, Z Xie, T Xia… - BioMed Research …, 2022 - Wiley Online Library
COVID‐19 is still prevalent in more world regions and poses a severe threat to human
health due to its high pathogenicity. The incidence of COPD patients is gradually increasing …

Association of cigarette smoking, COPD, and lung cancer with expression of SARS-CoV-2 entry genes in human airway epithelial cells

J Yin, B Kasper, F Petersen, X Yu - Frontiers in Medicine, 2020 - frontiersin.org
SARS-CoV-2 enters into human airway epithelial cells via membrane fusion or endocytosis,
and this process is dependent on ACE2, TMPRSS2, and cathepsin L. In this study, we …

Integrative transcriptomics analysis of lung epithelial cells and identification of repurposable drug candidates for COVID-19

T Islam, MR Rahman, B Aydin, H Beklen… - European Journal of …, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease, more commonly
COVID-19 has emerged as a world health pandemic. There are couples of treatment …

COVID-19 and cytokine storm

K Mukherjee - … Journal of Bioinformatics and Biological Science, 2020 - indianjournals.com
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes
coronavirus disease 2019 (COVID-19). As of October 31, 2020, the outbreak of COVID-19 …