Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results
AL Collins, Y Kim, P Sklar, MC O'Donovan… - Psychological …, 2012 - cambridge.org
BackgroundCandidate gene studies have been a key approach to the genetics of
schizophrenia (SCZ). However, the results of these studies are confusing and no genes …
schizophrenia (SCZ). However, the results of these studies are confusing and no genes …
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
DM Ruderfer, AW Charney, B Readhead… - The Lancet …, 2016 - thelancet.com
Background Therapeutic treatments for schizophrenia do not alleviate symptoms for all
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …
Joint contributions of rare copy number variants and common SNPs to risk for schizophrenia
Objective: Both rare copy number variants (CNVs) and common single-nucleotide
polymorphisms (SNPs) contribute to liability to schizophrenia, but their etiological …
polymorphisms (SNPs) contribute to liability to schizophrenia, but their etiological …
Increased schizophrenia family history burden and reduced premorbid IQ in treatment-resistant schizophrenia: a Swedish National Register and Genomic Study
A high proportion of those with schizophrenia experience treatment non-response, placing
them at higher risk for mortality and suicide attempts, compared to treatment responders …
them at higher risk for mortality and suicide attempts, compared to treatment responders …
De novo mutations from sporadic schizophrenia cases highlight important signaling genes in an independent sample
Schizophrenia is a debilitating syndrome with high heritability. Genomic studies reveal more
than a hundred genetic variants, largely nonspecific and of small effect size, and not …
than a hundred genetic variants, largely nonspecific and of small effect size, and not …
The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic review
Studying the phenotypic manifestations of increased genetic liability for schizophrenia can
increase our understanding of this disorder. Specifically, information from alleles identified in …
increase our understanding of this disorder. Specifically, information from alleles identified in …
[PDF][PDF] Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
Several lines of evidence suggest that genome-wide association studies (GWASs) have the
potential to explain more of the" missing heritability" of common complex phenotypes …
potential to explain more of the" missing heritability" of common complex phenotypes …
Thinking about schizophrenia in an era of genomic medicine
DR Weinberger - American Journal of Psychiatry, 2019 - Am Psychiatric Assoc
Genetic discoveries about human brain development and neuropsychiatric syndromes have
changed the landscape of psychiatric research. The genotyping of hundreds of thousands of …
changed the landscape of psychiatric research. The genotyping of hundreds of thousands of …
Genome‐wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness
Genome‐wide association studies (GWAS) of schizophrenia have yielded more than 100
common susceptibility variants, and strongly support a substantial polygenic contribution of …
common susceptibility variants, and strongly support a substantial polygenic contribution of …
Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes
Schizophrenia is a common mental disorder with high heritability and strong genetic
heterogeneity. Common disease-common variants hypothesis predicts that schizophrenia is …
heterogeneity. Common disease-common variants hypothesis predicts that schizophrenia is …