Exome arrays capture polygenic rare variant contributions to schizophrenia

AL Richards, G Leonenko, JT Walters… - Human molecular …, 2016 - academic.oup.com
Schizophrenia is a highly heritable disorder. Genome-wide association studies based
largely on common alleles have identified over 100 schizophrenia risk loci, but it is also …

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

CR Marshall, DP Howrigan, D Merico… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

EM Byrne, Z Zhu, T Qi, NG Skene, J Bryois… - Molecular …, 2021 - nature.com
Substantial genetic liability is shared across psychiatric disorders but less is known about
risk variants that are specific to a given disorder. We used multi-trait conditional and joint …

[HTML][HTML] Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

TB Bigdeli, G Genovese, P Georgakopoulos… - Molecular …, 2020 - nature.com
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting
tens of millions of individuals worldwide. While rare genetic variants play a role in the …

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

SH Lee, TR DeCandia, S Ripke, J Yang… - Nature …, 2012 - nature.com
Schizophrenia is a complex disorder caused by both genetic and environmental factors.
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …

[HTML][HTML] Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function

S Raychaudhuri, JM Korn, SA McCarroll… - PLoS …, 2010 - journals.plos.org
Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases,
such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes …

Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci

C Oldmeadow, D Mossman, TJ Evans… - Journal of psychiatric …, 2014 - Elsevier
Schizophrenia has a strong genetic basis, and genome-wide association studies (GWAS)
have shown that effect sizes for individual genetic variants which increase disease risk are …

Integrated post-GWAS analysis sheds new light on the disease mechanisms of schizophrenia

JR Lin, Y Cai, Q Zhang, W Zhang… - Genetics, 2016 - academic.oup.com
Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-
wide association studies (GWAS) have identified many schizophrenia-associated common …

The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare …

BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …

The genetic architecture of schizophrenia: review of large-scale genetic studies

H Kato, H Kimura, I Kushima, N Takahashi… - Journal of Human …, 2023 - nature.com
Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …