Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Tumors are supported by cancer-associated fibroblasts (CAFs). CAFs are heterogeneous
and carry out distinct cancer-associated functions. Understanding the full repertoire of CAFs …

Monocytes influence multiple aspects of tumor progression, including antitumor immunity,
angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor …

The introduction of a wide range of immunotherapies in clinical practice has revolutionized
the treatment of cancer in the last decade. The majority of these therapeutic modalities are …

Triple-negative (TN) breast cancers (ER− PR− HER2−) are highly metastatic and associated
with poor prognosis. Within this subtype, invasive, stroma-rich tumours with infiltration of …

Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …

Tumor associated macrophages (TAMs) are associated with tumor growth and metastasis.
MRI can detect TAMs labeled with iron oxide (USPIO) or perfluorocarbon (PFC) agents. This …

Recent preclinical/clinical studies have underscored the significant impact of tumor
microenvironment (TME) on tumor progression in diverse scenarios. Highly heterogeneous …

Background While the morbidity and mortality from cancer are largely attributable to its
metastatic dissemination, the integral features of the cascade are not well understood. The …

Background Tumor-associated macrophages (TAM) promote malignant progression, yet the
repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to …