Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen

MP Nyon, L Du, CTK Tseng, CA Seid, J Pollet… - Vaccine, 2018 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 2040
patients and caused 712 deaths since its first appearance in 2012, yet neither pathogen …

Optimization of antigen dose for a receptor-binding domain-based subunit vaccine against MERS coronavirus

J Tang, N Zhang, X Tao, G Zhao, Y Guo… - Human vaccines & …, 2015 - Taylor & Francis
Middle East respiratory syndrome (MERS) is an emerging infectious disease caused by
MERS coronavirus (MERS-CoV). The continuous increase of MERS cases has posed a …

Tailoring subunit vaccine immunity with adjuvant combinations and delivery routes using the Middle East respiratory coronavirus (MERS-CoV) receptor-binding …

J Lan, Y Deng, H Chen, G Lu, W Wang, X Guo, Z Lu… - PloS one, 2014 - journals.plos.org
The development of an effective vaccine is critical for prevention of a Middle East respiratory
syndrome coronavirus (MERS-CoV) pandemic. Some studies have indicated the receptor …

Current advancements and potential strategies in the development of MERS-CoV vaccines

N Zhang, S Jiang, L Du - Expert review of vaccines, 2014 - Taylor & Francis
Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by
a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β …

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus

N Zhang, R Channappanavar, C Ma, L Wang… - Cellular & molecular …, 2016 - nature.com
Middle East respiratory syndrome (MERS), an emerging infectious disease caused by
MERS coronavirus (MERS-CoV), has garnered worldwide attention as a consequence of its …

Prospects for a MERS-CoV spike vaccine

Y Zhou, S Jiang, L Du - Expert review of vaccines, 2018 - Taylor & Francis
Introduction: Six years have passed since Middle East respiratory syndrome (MERS)
coronavirus (MERS-CoV), a newly emerging infectious virus, was first reported in 2012 …

Advances in MERS-CoV vaccines and therapeutics based on the receptor-binding domain

Y Zhou, Y Yang, J Huang, S Jiang, L Du - Viruses, 2019 - mdpi.com
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus
that was first reported in 2012. The MERS-CoV genome encodes four major structural …

A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike …

L Du, G Zhao, Y Yang, H Qiu, L Wang, Z Kou… - Journal of …, 2014 - Am Soc Microbiol
Prophylactic and therapeutic strategies are urgently needed to combat infections caused by
the newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we …

Cross-protection against MERS-CoV by prime-boost vaccination using viral spike DNA and protein

J Choi, J Goo, E Yang, DI Jung, S Lee, S Rho… - Journal of …, 2020 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory
illness and has a high mortality of∼ 34%. However, since its discovery in 2012, an effective …

Characterization of the immune response of MERS-CoV vaccine candidates derived from two different vectors in mice

E Li, F Yan, P Huang, H Chi, S Xu, G Li, C Liu, N Feng… - Viruses, 2020 - mdpi.com
Middle East respiratory syndrome (MERS) is an acute, high-mortality-rate, severe infectious
disease caused by an emerging MERS coronavirus (MERS-CoV) that causes severe …