Lewis Acid Catalyzed Tandem 1,4-Conjugate Addition/Cyclization of in Situ Generated Alkynyl o-Quinone Methides and Electron-Rich Phenols: Synthesis of …

JY Du, YH Ma, FX Meng, BL Chen, SL Zhang… - Organic …, 2018 - ACS Publications
A versatile Lewis acid catalyzed tandem cyclization of in situ generated alkynyl o-quinone
methides (o-AQMs) with electron-rich phenols has been developed on the basis of the mode …

Formal [4+2] Cycloaddition of oAza‐Quinone Methide for the Synthesis of 1,4‐Heterocycle‐Fused Quinolines

SJ Gharpure, SK Nanda… - Advanced Synthesis & …, 2021 - Wiley Online Library
A protocol involving intramolecular formal [4+ 2]‐cycloaddition of in situ generated o‐aza‐
quinone methide for the facile synthesis of 1, 4‐heterocycle‐fused quinoline motifs is …

Gold (iii)-catalyzed azide-yne cyclization/O–H insertion cascade reaction for the expeditious construction of 3-alkoxy-4-quinolinone frameworks

J Huang, H Su, M Bao, L Qiu, Y Zhang… - Organic & Biomolecular …, 2020 - pubs.rsc.org
A gold-catalyzed 6-endo-dig azide-yne cyclization/O–H insertion cascade reaction of azide-
tethered alkynes with alcohols has been developed, and it provides an expeditious access …

Radical Deaminative ipso-Cyclization of 4-Methoxyanilines with 1,7-Enynes for Accessing Spirocyclohexadienone-Containing Cyclopenta[c]quinolin-4-ones

J Li, WW Zhang, XJ Wei, F Liu, WJ Hao… - The Journal of …, 2017 - ACS Publications
A new C-center radical-triggered bicyclization cascade of N-tethered 1, 7-enynes for forming
28 examples of biologically interesting spirocyclohexadienone-containing cyclopenta [c] …

Base-mediated diastereoselective [4+ 3] annulation of in situ generated ortho-quinone methides with C, N-cyclic azomethine imines

J Xu, S Yuan, J Peng, M Miao, Z Chen… - Organic & Biomolecular …, 2017 - pubs.rsc.org
An efficient [4+ 3] annulation of 2-(1-tosylalkyl) phenols with C, N-cyclic azomethine imines
via in situ generation of ortho-quinone methides (o-QMs) under mild basic reaction …

Domino N2-Extrusion–Cyclization of Alkynylarylketone Derivatives for the Synthesis of Indoloquinolines and Carbocycle-Fused Quinolines

B Akkachairin, J Tummatorn… - The Journal of …, 2018 - ACS Publications
New synthetic approaches for the synthesis of indoloquinolines and carbocycle-fused
quinolines have been developed employing alkynylketone substrates. These synthetic …

(4+ 2) cyclization of aza-o-quinone methides with azlactones: construction of biologically important dihydroquinolinone frameworks

HQ Wang, W Ma, A Sun, XY Sun, C Jiang… - Organic & …, 2021 - pubs.rsc.org
A base-promoted (4+ 2) cyclization of aza-o-quinone methides (aza-o-QMs) in situ
generated from N-(o-chloromethyl) aryl amides was established. In this approach …

Hydrazone-oxime Selectively Directed Redox-Neutral [4 + 2] Annulations Cascade with Alkynes and Iodonium Ylides to Build 1,1′-Biisoquinoline Mono-N-oxides

C Wen, Y Wang, Y Yang, YN Tian, J Wang, S Li - Organic Letters, 2023 - ACS Publications
Selective C–H activation of a molecule containing multiple directing groups is an important
but challenging issue in organic chemistry. Herein, a combined directing group (hydrazone …

A highly diastereoselective [5+ 1] annulation to 2, 2, 3-trisubstituted tetrahydroquinoxalines via intramolecular Mannich-type trapping of ammonium ylides

XY Guan, M Tang, ZQ Liu, WH Hu - Chemical Communications, 2019 - pubs.rsc.org
A novel tandem intermolecular ammonium ylide formation/intramolecular Mannich-type [5+
1] cyclization reaction of aryl diazoacetates and ortho-aminophenyl imine derivatives was …

Synthesis of a fused N-bridged [3.3. 1] nonadiquinoline multicyclic skeleton via a metal-free formal [4+ 2] cycloaddition/Mannich/dearomatization domino reaction

K Amiri, B Nayebzadeh, M Kamangar, M Babazadeh… - Green …, 2023 - pubs.rsc.org
We present a novel green synthetic protocol for the construction of a broad range of
substituted fused azabicyclo [3.3. 1] nonadiquinoline scaffolds through a formic acid …