Mobile compensatory mutations promote plasmid survival
The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …
issue for human health and society. While the fitness costs for host cells associated with …
[HTML][HTML] Interactions between plasmids and other mobile genetic elements affect their transmission and persistence
Plasmids are genetic elements that play a role in bacterial evolution by providing new genes
that promote adaptation to diverse conditions. Plasmids are also known to reduce bacterial …
that promote adaptation to diverse conditions. Plasmids are also known to reduce bacterial …
Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance
Multidrug resistant bacterial pathogens have become a serious global human health threat,
and conjugative plasmids are important drivers of the rapid spread of resistance to last …
and conjugative plasmids are important drivers of the rapid spread of resistance to last …
Antibiotics interfere with the evolution of plasmid stability
Extra-chromosomal genetic elements are important drivers of bacterial evolution, and their
evolutionary success depends on positive selection for the genes they encode. Examples …
evolutionary success depends on positive selection for the genes they encode. Examples …
Plasmid viability depends on the ecological setting of hosts within a multiplasmid community
C Given, R Penttinen, M Jalasvuori - Microbiology Spectrum, 2022 - Am Soc Microbiol
Plasmids are extrachromosomal genetic elements, some of which disperse horizontally
between different strains and species of bacteria. They are a major factor in the …
between different strains and species of bacteria. They are a major factor in the …
Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance
T Dimitriu, AC Matthews… - Proceedings of the …, 2021 - National Acad Sciences
Conjugative plasmids are mobile elements that spread horizontally between bacterial hosts
and often confer adaptive phenotypes, including antimicrobial resistance (AMR). Theory …
and often confer adaptive phenotypes, including antimicrobial resistance (AMR). Theory …
Fitness costs of plasmids: a limit to plasmid transmission
A San Millan, RC MacLean - Microbiology spectrum, 2017 - Am Soc Microbiol
Plasmids mediate the horizontal transmission of genetic information between bacteria,
facilitating their adaptation to multiple environmental conditions. An especially important …
facilitating their adaptation to multiple environmental conditions. An especially important …
The evolution of plasmid-carried antibiotic resistance
Background Antibiotic resistance represents a significant public health problem. When
resistance genes are mobile, being carried on plasmids or phages, their spread can be …
resistance genes are mobile, being carried on plasmids or phages, their spread can be …
Evolutionary paths that expand plasmid host-range: implications for spread of antibiotic resistance
W Loftie-Eaton, H Yano, S Burleigh… - Molecular biology …, 2016 - academic.oup.com
Abstract The World Health Organization has declared the emergence of antibiotic resistance
to be a global threat to human health. Broad-host-range plasmids have a key role in causing …
to be a global threat to human health. Broad-host-range plasmids have a key role in causing …
Plasmid interactions can improve plasmid persistence in bacterial populations
It is difficult to understand plasmid maintenance in the absence of selection and theoretical
models predict the conditions for plasmid persistence to be limited. Plasmid-associated …
models predict the conditions for plasmid persistence to be limited. Plasmid-associated …