With the recent advent of immunotherapy, there is a critical need to understand immune cell
interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts …

Purpose: Throughout their development, tumors are challenged by the immune system, and
they acquire features to evade its surveillance. A systematic view of these traits, which shed …

During the course of tumorigenesis and subsequent metastasis, malignant cells gradually
diversify and become more heterogeneous. Consequently, the tumor mass might be …

Understanding the tumor microenvironment is important to efficiently identify appropriate
patients for immunotherapies in a variety of cancers. Here, we presented the tumor …

Although recent cancer immunotherapy strategies, including immune-checkpoint blockade
(ie blocking PD-1, PD-L1 or CTLA-4), have shown durable clinical effects in some (but not …

Cancers display significant heterogeneity with respect to tissue of origin, driver mutations,
and other features of the surrounding tissue. It is likely that individual tumors engage …

Background Cancer immunity is based on the interaction of a multitude of cells in the spatial
context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated …

Therapeutic options for the treatment of an increasing variety of cancers have been
expanded by the introduction of a new class of drugs, commonly referred to as checkpoint …

We performed an extensive immunogenomic analysis of more than 10,000 tumors
comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer …

Background Tumor-infiltrating leukocytes can either limit cancer growth or facilitate its
spread. Diagnostic strategies that comprehensively assess the functional complexity of …