Objectives Clinical manifestations of sickle cell disease (SCD) result from sickling of Hb S
due to oxidation, which is augmented by accumulation of oxygen-free radicals. Deficiencies …

Sickle cell disease (SCD) complications are associated with oxidative stress. Glutathione S-
transferases (GSTs) are a group of enzymes that protect against oxidative stress. The aims …

Background: Glutathione system plays an important role in the protection of cells and tissue
against damage from oxidative stress. Impairment of the glutathione system due to genetic …

Glutathione S-transferase gene deletions are known detoxification agents and cause
oxidative damage. In different studies, variations in null allele frequency have been …

The hereditary deficiency of antioxidant enzymes when associated with sickle cell anemia
(SCA) further contributes to the oxidation of hemoglobin S, which increases the formation of …

Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most
common enzymopathy affecting millions of individuals worldwide. It is believed that the …

This study evaluated the oxidative stress and antioxidant capacity markers in sickle cell
anemia (SCA) patients with and without treatment with hydroxyurea. We assessed GSTT1 …

BACKGROUND: Glutathione S-transferase gene deletions are known detoxification agents
and cause oxidative damage. Due to the different pathophysiology of anemia in thalassemia …

Continuous reactive oxygen species (ROS) production in individuals with sickle cell disease
(SCD) may alter their overall redox status and cause tissue damage. The aim of this study …

Background Oxidative stress constitutes one of the significant cause of vaso-occlusive
clinical episodes in sickle cell disease (SCD) patients. It brings about the generation of …