Plasmid viability depends on the ecological setting of hosts within a multiplasmid community

C Given, R Penttinen, M Jalasvuori - Microbiology Spectrum, 2022 - Am Soc Microbiol
Plasmids are extrachromosomal genetic elements, some of which disperse horizontally
between different strains and species of bacteria. They are a major factor in the …

Interspecific competition can drive the loss of conjugative plasmids from a focal species in a microbial community

D Walker-Sünderhauf, U Klümper, WH Gaze… - bioRxiv, 2022 - biorxiv.org
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, and
it is therefore critical to predict and reduce plasmid spread within microbial communities. The …

Progress towards understanding the fate of plasmids in bacterial communities

FR Slater, MJ Bailey, AJ Tett… - FEMS microbiology …, 2008 - academic.oup.com
Plasmid-mediated horizontal gene transfer influences bacterial community structure and
evolution. However, an understanding of the forces which dictate the fate of plasmids in …

[HTML][HTML] Interactions between plasmids and other mobile genetic elements affect their transmission and persistence

F Dionisio, R Zilhão, JA Gama - Plasmid, 2019 - Elsevier
Plasmids are genetic elements that play a role in bacterial evolution by providing new genes
that promote adaptation to diverse conditions. Plasmids are also known to reduce bacterial …

The dilution effect limits plasmid horizontal transmission in multispecies bacterial communities

A Kottara, L Carrilero, E Harrison, JPJ Hall… - …, 2021 - microbiologyresearch.org
By transferring ecologically important traits between species, plasmids drive genomic
divergence and evolutionary innovation in their bacterial hosts. Bacterial communities are …

Interspecific competition can drive plasmid loss from a focal species in a microbial community

D Sünderhauf, U Klümper, WH Gaze… - The ISME …, 2023 - academic.oup.com
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, and
it is therefore critical to predict and reduce plasmid spread within microbial communities. The …

Plasmid interactions can improve plasmid persistence in bacterial populations

JA Gama, R Zilhão, F Dionisio - Frontiers in Microbiology, 2020 - frontiersin.org
It is difficult to understand plasmid maintenance in the absence of selection and theoretical
models predict the conditions for plasmid persistence to be limited. Plasmid-associated …

Plasmid Costs Explain Plasmid Maintenance, Irrespective of the Nature of Compensatory Mutations

JS Rebelo, CPF Domingues, F Dionisio - Antibiotics, 2023 - mdpi.com
Conjugative plasmids often carry virulence and antibiotic-resistant genes. Therefore,
understanding the behavior of these extra-chromosomal DNA elements gives insights into …

Rapid evolution helps bacteria to pick up a plasmid

M Bottery, MA Brockhurst - Proceedings of the National …, 2023 - National Acad Sciences
Rising rates of antimicrobial resistance (AMR) are a threat to global health. The spread of
AMR genes in bacteria is driven to a large extent by the action of plasmids (1). Plasmids are …

Mobile compensatory mutations promote plasmid survival

M Zwanzig, E Harrison, MA Brockhurst, JPJ Hall… - Msystems, 2019 - Am Soc Microbiol
The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …