Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious
global health issue. Remdesivir is the first antiviral compound approved by the US FDA for …

Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals.
Infection by CoVs such as HCoV-229E,-NL63,-OC43 and-HKU1 leads to the common cold …

The RNA-dependent RNA polymerase (RdRp) is a key enzyme which regulates the viral
replication of SARS-CoV-2. Remdesivir (RDV) is clinically used drug which targets RdRp …

Rapid changes in the viral genome allow viruses to evade threats posed by the host immune
response or antiviral drugs, and can lead to viral persistence in the host cells. RNA …

Nirmatrelvir is an orally available inhibitor of SARS-CoV-2 main protease (Mpro) and the
main ingredient of PAXLOVID, a drug approved by FDA for high-risk COVID-19 patients …

Introduction Despite all the efforts to treat COVID-19, no particular cure has been found for
this virus. Since developing antiviral drugs is a time-consuming process, the most effective …

RNA-dependent RNA polymerase (RdRp), also known as nsp12, is a key component in the
synthesis of viral ribonucleic acid (RNA) and is considered the primary target of nucleoside …

Despite strict measures taken by many countries, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) continues to be an issue of global concern. Currently, there are …

The SARS-cov-2 RNA dependent RNA polymerase (nsp12) is a crucial viral enzyme that
catalyzes the replication of RNA from RNA templates. The fixation of some ligands in the …

We combine molecular dynamics, statistical mechanics, and hybrid quantum
mechanics/molecular mechanics simulations to describe mechanistically the severe acute …