Impact of remdesivir incorporation along the primer strand on SARS-CoV-2 RNA-Dependent RNA polymerase
S Naseem-Khan, MB Berger, EM Leddin… - Journal of chemical …, 2022 - ACS Publications
Remdesivir was the first antiviral drug that received emergency use authorization from the
United States Food and Drug Administration and is now formally approved to treat COVID …
United States Food and Drug Administration and is now formally approved to treat COVID …
[HTML][HTML] Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: a molecular …
P Indu, MR Rameshkumar, N Arunagirinathan… - Journal of Infection and …, 2020 - Elsevier
Background Outbreak of COVID-19 has been recognized as a global health concern since it
causes high rates of morbidity and mortality. No specific antiviral drugs are available for the …
causes high rates of morbidity and mortality. No specific antiviral drugs are available for the …
Denovo designing, retro-combinatorial synthesis, and molecular dynamics analysis identify novel antiviral VTRM1. 1 against RNA-dependent RNA polymerase of …
V Tiwari - International journal of biological macromolecules, 2021 - Elsevier
A novel coronavirus disease (COVID-19) caused by SARS-CoV2 has now spread globally.
Replication/transcription machinery of this virus consists of RNA-dependent RNA …
Replication/transcription machinery of this virus consists of RNA-dependent RNA …
Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
Y Gao, L Yan, Y Huang, F Liu, Y Zhao, L Cao, T Wang… - BioRxiv, 2020 - biorxiv.org
Abstract A novel coronavirus (2019-nCoV) outbreak has caused a global pandemic resulting
in tens of thousands of infections and thousands of deaths worldwide. The RNA-dependent …
in tens of thousands of infections and thousands of deaths worldwide. The RNA-dependent …
Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase
The recent pandemic associated with SARS-CoV-2, a virus of the Coronaviridae family, has
resulted in an unprecedented number of infected people. The highly contagious nature of …
resulted in an unprecedented number of infected people. The highly contagious nature of …
[PDF][PDF] Early combination treatment with existing HIV antivirals: an effective treatment for COVID-19?
OBJECTIVE: Since no effective therapy exists, we aimed to test existing HIV antivirals for
combination treatment of Coronavirus disease 19 (COVID-19). MATERIALS AND …
combination treatment of Coronavirus disease 19 (COVID-19). MATERIALS AND …
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19
AA Elfiky - Life sciences, 2020 - Elsevier
Aims A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan,
China (COVID-19). Until today> 2700 deaths from the 80,000 confirmed cases reported …
China (COVID-19). Until today> 2700 deaths from the 80,000 confirmed cases reported …
[HTML][HTML] Molecular dynamics simulations reveal the interaction fingerprint of remdesivir triphosphate pivotal in allosteric regulation of SARS-CoV-2 RdRp
The COVID-19 pandemic has now strengthened its hold on human health and coronavirus'
lethal existence does not seem to be going away soon. In this regard, the optimization of …
lethal existence does not seem to be going away soon. In this regard, the optimization of …
Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation
COVID-19, a disease caused by a new strain of coronavirus (SARS-CoV-2) originating from
Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the …
Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the …
[HTML][HTML] Nirmatrelvir exerts distinct antiviral potency against different human coronaviruses
Nirmatrelvir is the main component of Paxlovid, an oral antiviral drug approved for the
treatment of COVID-19 caused by SARS-COV-2 infection. Nirmatrelvir targets the main …
treatment of COVID-19 caused by SARS-COV-2 infection. Nirmatrelvir targets the main …