MI Ryder - Journal of periodontology, 2020 - Wiley Online Library
Epidemiological studies have identified an association between periodontitis and Alzheimer disease (AD); however, the nature of this association has been unclear. Recent work …
I Olsen, SK Singhrao - Expert Review of Anti-infective Therapy, 2020 - Taylor & Francis
Generalized ('chronic') periodontitis, a common inflammatory disease affecting the supporting tissues of teeth, has been associated with several systemic diseases, eg …
U Haditsch, T Roth, L Rodriguez… - Journal of …, 2020 - content.iospress.com
Background: Porphyromonas gingivalis (P. gingivalis) and its gingipain virulence factors have been identified as pathogenic effectors in Alzheimer's disease (AD). In a recent study …
SS Dominy, C Lynch, F Ermini, M Benedyk… - Science …, 2019 - science.org
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called …
S Liu, CA Butler, S Ayton, EC Reynolds… - Critical Reviews in …, 2024 - Taylor & Francis
The cause of Alzheimer's disease (AD), and the pathophysiological mechanisms involved, remain major unanswered questions in medical science. Oral bacteria, especially those …
SK Singhrao, A Harding, S Poole… - Mediators of …, 2015 - Wiley Online Library
Periodontal disease (PD) and Alzheimer's disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex …
I Olsen - Frontiers in Neuroscience, 2021 - frontiersin.org
“Chronic” periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer's disease (AD). Pathological hallmarks in AD are …
SK Singhrao, I Olsen - Journal of oral microbiology, 2019 - Taylor & Francis
Chronic periodontitis of 10 years' duration is reported to become a twofold risk factor for the development of Alzheimer's disease (AD). Periodontitis is modifiable, and this fits with the …
Porphyromonas gingivalis is a Gram-negative, rod-shaped, obligate anaerobe that obtains its metabolic energy from protein breakdown products, heme, and vitamin K for its growth. It …