[HTML][HTML] ZDQ-0620, a novel phosphatidylinositol 3-kinase inhibitor, inhibits colorectal carcinoma cell proliferation and suppresses angiogenesis by attenuating PI3K …
X Qin, M Liu, C Xu, B Xing, X Xu, Y Wu, H Ding… - Frontiers in …, 2022 - frontiersin.org
The PI3K/AKT pathway plays a central role in human cancers, aberrant activation of this
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
[HTML][HTML] β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K
S Nie, L Chang, Y Huang, H Zhou, Q Yang… - Natural Products and …, 2024 - Springer
Abstract Phosphoinositide 3-kinase (PI3Ks) are lipid kinases widely involved in cell
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K …
KH Jung, MJ Choi, S Hong, H Lee, SW Hong… - Cancer letters, 2012 - Elsevier
The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation
and survival of human cancers. As PI3K is active in many cancer patients, resulting in cancer …
and survival of human cancers. As PI3K is active in many cancer patients, resulting in cancer …
A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis
A Hussain, AK Qazi, N Mupparapu… - Molecular …, 2016 - Wiley Online Library
Phosphatidylinositol‐3‐kinase (PI3K) pathway deregulation is responsible for initiation,
chemo‐resistance, and poor prognosis of colorectal cancer (CRC). Therefore, PI3K pathway …
chemo‐resistance, and poor prognosis of colorectal cancer (CRC). Therefore, PI3K pathway …
Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer
F Yang, JY Gao, H Chen, ZH Du, XQ Zhang… - OncoTargets and …, 2017 - Taylor & Francis
Background Colon cancer is the third most common cancer in the world, and its metastasis
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
Novel 4-aminoquinazoline derivatives induce growth inhibition, cell cycle arrest and apoptosis via PI3Kα inhibition
YH Fan, HW Ding, DD Liu, HR Song, YN Xu… - Bioorganic & Medicinal …, 2018 - Elsevier
Abstract Phosphatidylinositol 3-kinase (PI3K) signaling pathway has diverse functions,
including the regulation of cellular survival, proliferation, cell cycle, migration, angiogenesis …
including the regulation of cellular survival, proliferation, cell cycle, migration, angiogenesis …
DZW-310, a novel phosphoinositide 3-kinase inhibitor, attenuates the angiogenesis and growth of hepatocellular carcinoma cells via PI3K/AKT/mTOR axis
Y Wu, X Xu, M Liu, X Qin, Q Wu, H Ding… - Biochemical …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most malignant tumors worldwide with high
lethality and prevalence. The deregulated phosphoinositide 3-kinase/protein kinase …
lethality and prevalence. The deregulated phosphoinositide 3-kinase/protein kinase …
Inhibition of PI3K/AKT signaling using BKM120 reduced the proliferation and migration potentials of colorectal cancer cells and enhanced cisplatin-induced …
Background Although extensive efforts have been made to improve the treatment of
colorectal cancer (CRC) patients, the prognosis for these patients remains poor. A wide …
colorectal cancer (CRC) patients, the prognosis for these patients remains poor. A wide …
Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth
Abstract Phosphatidylinositol 3-kinase (PI3K) pathway drives cancer progression through
direct regulation of most oncogenic properties. Here, we report that PI3K pathway signaling …
direct regulation of most oncogenic properties. Here, we report that PI3K pathway signaling …
[HTML][HTML] DHW-208, A novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-hepatocellular carcinoma activity through promoting apoptosis and inhibiting …
S Wang, Y Wu, M Liu, Q Zhao, L Jian - Frontiers in Oncology, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide with high
prevalence and lethality. Due to insidious onset and lack of early symptoms, most HCC …
prevalence and lethality. Due to insidious onset and lack of early symptoms, most HCC …