Background Studies suggest that Wilms tumours (WT) are caused by underlying genetic (5%–
10%) and epigenetic (2%–29%) mechanisms, yet studies covering both aspects are sparse …

PURPOSE Wilms tumor (WT) is associated with (epi) genetic predisposing factors affecting a
growing number of WT predisposing genes and loci, including those causing Beckwith …

Abstract Wilms' tumor (WT), the most common childhood kidney cancer, develops in
association with an underlying germline predisposition in up to 15% of cases. Germline …

This study comprehensively evaluated the landscape of genetic and epigenetic events that
predispose to synchronous bilateral Wilms tumor (BWT). We performed whole exome or …

Developing synchronous bilateral Wilms tumor suggests an underlying (epi) genetic
predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or …

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Background Wilms tumor (WT) exhibits structural and epigenetic changes at chromosome
11p15, which also cause Beckwith-Wiedemann Syndrome (BWS). Children diagnosed with …

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are
implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we …

Abstract Background Wilms Tumor (WT) can occur in association with tumor predisposition
syndromes and/or with clinical malformations. These associations have not been fully …

Background Wilms tumour is the most common childhood renal cancer and is genetically
heterogeneous. While several Wilms tumour predisposition genes have been identified …