Aflatoxins belong to a family of decaketides that are produced as secondary metabolites by
Aspergillus flavus and A. parasiticus. The aflatoxin biosynthetic pathway involves several …

Aflatoxins are extremely potent carcinogens produced by Aspergillus flavus and Aspergillus
parasiticus. Cloning of genes in the aflatoxin pathway provides a specific approach to …

We studied the role of the regulatory gene aflR and its product, AflR, in the biosynthesis of
aflatoxin in Aspergillus. Western blot and enzyme-linked immunosorbent assay analyses …

Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi
Aspergillus flavus and A. parasiticus. Aflatoxins are synthesized by condensation of acetate …

abstract Aflatoxin contamination of food and feed is a major concern due to the carcinogenic
properties of this mycotoxin. Previous studies using classical approaches have identified a …

An Aspergillus parasiticus gene, designated apa-2, was identified as a regulatory gene
associated with aflatoxin biosynthesis. The apa-2 gene was cloned on the basis of …

The genes encoding the aflatoxin biosynthetic pathway enzymes have been localized as a
cluster to a 75-kb DNA fragment. The enzymatic functions of the products of most of the …

The aflR gene from Aspergillus parasiticus and Aspergillus flavus may be involved in the
regulation of aflatoxin biosynthesis. The aflR gene product, AFLR, possesses a GAL4-type …

The Aspergillus parasiticus aflJ gene, which is located in the aflatoxin biosynthetic gene
cluster and is transcribed divergently from the aflatoxin pathway regulatory gene aflR …

Aflatoxins are secondary metabolites produced by Aspergillus flavus and Aspergillus
parasiticus. Most of the genes involved in the biosynthesis of aflatoxin are contained within a …