Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. The
major pathological consequences of IHD arise from the detrimental effects of acute ischemia …

Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Cardioprotective strategies aim to salvage myocardium from ischemia/reperfusion injury and
to reduce infarct size and its consequences. Different stimuli, acting at sites remote from the …

Brief transient episodes of nonlethal myocardial ischemia protect or “precondition” the heart
and render the myocardium resistant to a subsequent more sustained ischemic insult. The …

Cardioprotective mechanisms such as acute or early preconditioning activate several
primary signaling pathways that seem to converge on mitochondrial targets, leading to …

The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

We and others found that cardioprotection is acquired not only soon after, but also 24 h after
ischemic preconditioning in canine and rabbit myocardial infarction models (second window …

Novel treatment approaches, as potential adjunctive therapy to current reperfusion
strategies (such as thrombolysis, primary coronary angioplasty, and cardiac surgery), are …

Coronary heart disease (CHD) is the leading cause of death worldwide. The development of
novel treatment strategies for protecting the myocardium against the detrimental effects of …

• Introduction• Reperfusion injury‐Causes of reperfusion injury‐Effects of reperfusion injury•
Definition of postconditioning‐Postconditioning algorithm• Protective effects of …