NF-κB as a target for modulating inflammatory responses

C Gasparini, M Feldmann - Current pharmaceutical design, 2012 - ingentaconnect.com
The inflammatory response is of major importance in host defence, but is involved in all
acute and chronic diseases. Multiple inflammatory cells and molecules are involved. Among …

NF-κB as a therapeutic target in chronic inflammation: recent advances

SS Makarov - Molecular medicine today, 2000 - cell.com
The family of nuclear factor κB (NF-κB) transcription factors is a topic of intense interest in the
biomedical community stemming from the role NF-κB plays in almost every aspect of cell …

Nuclear factor kappa B—molecular biomedicine: the next generation

P Celec - Biomedicine & pharmacotherapy, 2004 - Elsevier
Nuclear factor kappa B (NFκB) as a transcription factor plays an important integrating role in
the intracellular regulation of immune response, inflammation and cell cycle regulation …

Potential pharmacological control of the NF-κB pathway

G Sethi, V Tergaonkar - Trends in pharmacological sciences, 2009 - cell.com
Nuclear factor (NF)-κB governs the expression of numerous genes that are important for
various cellular responses. Its activation is induced by a wide variety of stimuli including …

A beginner's guide to NF‐κB signaling pathways

S Delhalle, R Blasius, M Dicato… - Annals of the New York …, 2004 - Wiley Online Library
Nuclear factor κB (NF‐κB) belongs to a family of heterodimeric transcription factors that play
a key role in inflammatory and stress responses as well as in tumor cell resistance to …

NF-κB signaling and inflammation—Drug repurposing to treat inflammatory disorders?

A Roberti, LE Chaffey, DR Greaves - Biology, 2022 - mdpi.com
Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

The proinflammatory transcription factor NFκB: a potential target for novel therapeutical strategies

P Renard, M Raes - Cell biology and toxicology, 1999 - Springer
NFκB is a ubiquitous transcription factor involved in the proinflammatory response to
cytokines (such as IL-1 or TNF-α) and some particular stresses. The unraveling of the …

NF-κB signaling in inflammation

T Liu, L Zhang, D Joo, SC Sun - Signal transduction and targeted …, 2017 - nature.com
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …

Nuclear factor-κB1: regulation and function

SG Pereira, F Oakley - The international journal of biochemistry & cell …, 2008 - Elsevier
The transcription factor NF-κB is a critical regulator of many cellular processes including cell
survival and inflammation. NF-κB functions as a hetero-or homo-dimer which can be formed …

Nuclear factor-κB

PJ Barnes - The international journal of biochemistry & cell biology, 1997 - Elsevier
Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor that, by regulating the
expression of multiple inflammatory and immune genes, plays a critical role in host defence …