Rapidly increasing demand for cell-derived products has placed huge pressures on the
biomanufacturing industry's production capacity requirements. Media development …

Optimized cell-culture media is essential to enhance production of a quality
biopharmaceutical product. In the past decade, the biopharmaceutical industry has …

Culture media development continues to be an area that offers the potential to dramatically
improve the productivity of biopharmaceutical manufacturing processes. Having a well …

Not long ago, the ability to support efficient large-scale culture of cells was the main factor in
choice and development of production media. However, a number of new performance …

JUNE 2005 BioProcess International 39 SUPPLEMENT reduce the rate of hybridoma
viability decline and improve monoclonal antibody productivity. The considered …

Cell culture medium plays a significant role in determining the cell density, viability, and
productivity of a robust manufacturing process. Current regulatory requirements prefer …

» Up to 60% of product development costs are associated with process development for
producing clinical materials.«significantly improved by increasing the transcription and …

Fed‐batch cell culture processes are the standard platform technology for the synthesis of
high value biopharmaceutical proteins. Recent advances in cell line development and in the …

Advantages of using internally developed chemically‐defined (CD) media for cell culture‐
based therapeutic protein production over commercial media include better raw material …

The design of basal and feed media in mammalian cell culture is paramount towards
ensuring acceptable upstream process performance in various operation modes, especially …