Background Pulmonary hyperinflammation is a key event with SARS-CoV-2 infection. Acute
respiratory distress syndrome (ARDS) that often accompanies COVID-19 appears to have …

Background: Hyperinflammation is a key event that occurs with SARS-CoV-2 infection. In the
lung, hyperinflammation leads to structural damage to tissue. To date, numerous lung …

Background Progressive respiratory failure is the primary cause of death in the coronavirus
disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of …

Severe coronavirus disease-19 (COVID-19) is characterized by vascular inflammation and
thrombosis. We and others have proposed that the inflammatory response to coronavirus …

COVID-19 has been considered a vascular disease, and inflammation, intravascular
coagulation, and consequent thrombosis may be associated with endothelial dysfunction …

Objective: SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a
major cause of morbidity and mortality, often as a result of acute respiratory distress …

Objective: Alveolar-capillary endothelial cells can be activated by severe acute respiratory
syndrome coronavirus 2 infection leading to cytokine release. This could trigger endothelial …

The outbreak of COVID-19 disease, caused by SARS-CoV-2 beta-coronovirus, urges a
focused search for the underlying mechanisms and treatment options. The lung is the major …

Objective The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2,
triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome …

Background Pulmonary involvement in COVID-19 is characterized pathologically by diffuse
alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory …