COVID-19/SARS-CoV-2 infection: lysosomes and lysosomotropism implicate new treatment strategies and personal risks
M Blaess, L Kaiser, M Sauer, R Csuk… - International journal of …, 2020 - mdpi.com
In line with SARS and MERS, the SARS-CoV-2/COVID-19 pandemic is one of the largest
challenges in medicine and health care worldwide. SARS-CoV-2 infection/COVID-19 …
challenges in medicine and health care worldwide. SARS-CoV-2 infection/COVID-19 …
Potential antiviral strategy exploiting dependence of SARS-CoV-2 replication on lysosome-based pathway
Y Lan, W He, G Wang, Z Wang, Y Chen, F Gao… - International Journal of …, 2022 - mdpi.com
The recent novel coronavirus (SARS-CoV-2) disease (COVID-19) outbreak created a severe
public health burden worldwide. Unfortunately, the SARS-CoV-2 variant is still spreading at …
public health burden worldwide. Unfortunately, the SARS-CoV-2 variant is still spreading at …
The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small molecules
K Gorshkov, CZ Chen, R Bostwick… - ACS infectious …, 2020 - ACS Publications
Understanding the SARS-CoV-2 virus' pathways of infection, virus–host–protein interactions,
and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and …
and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and …
Widely available lysosome targeting agents should be considered as potential therapy for COVID-19
While the coronavirus disease 2019 (COVID-19) pandemic advances, the scientific
community continues to struggle in the search for treatments. Several improvements have …
community continues to struggle in the search for treatments. Several improvements have …
Lysosome activation in peripheral blood mononuclear cells and prognostic significance of circulating LC3B in COVID-19
Abstract Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, causing
significant mortality. There is a mechanistic relationship between intracellular coronavirus …
significant mortality. There is a mechanistic relationship between intracellular coronavirus …
Amantadine disrupts lysosomal gene expression; potential therapy for COVID19
SP Smieszek, BP Przychodzen, MH Polymeropoulos - BioRxiv, 2020 - biorxiv.org
SARS-coronavirus 2 is the causal agent of the COVID-19 outbreak. SARS-Cov-2 entry into a
cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on …
cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on …
[HTML][HTML] Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19
U Norinder, A Tuck, K Norgren, VM Kos - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Given the speed of viral infection spread, repurposing of existing drugs has been given the
highest priority in combating the ongoing COVID-19 pandemic. Only drugs that are already …
highest priority in combating the ongoing COVID-19 pandemic. Only drugs that are already …
Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment
SP Smieszek, BP Przychodzen… - International journal of …, 2020 - Elsevier
SARS-coronavirus 2 is the causal agent of the COVID-19 outbreak. SARS-Cov-2 entry into a
cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on …
cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on …
[HTML][HTML] The lysosome: a potential juncture between SARS‐CoV‐2 infectivity and Niemann‐Pick disease type C, with therapeutic implications
Drug repurposing is potentially the fastest available option in the race to identify safe and
efficacious drugs that can be used to prevent and/or treat COVID‐19. By describing the life …
efficacious drugs that can be used to prevent and/or treat COVID‐19. By describing the life …
[HTML][HTML] Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19
N Yang, HM Shen - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA
viruses and some of them are known to cause severe respiratory diseases in human …
viruses and some of them are known to cause severe respiratory diseases in human …