Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …

Apoptosis is a naturally occurring mechanism of cell death that plays an important role in
both normal and pathological remodeling of the vessel wall. Abdominal aortic aneurysms …

As the primary causes of myocardial infarction, stroke, atherosclerosis, in-stent restenosis,
and aneurysm, aortic diseases pose a serious threat to human health. Arterial remodeling is …

Aortic aneurysm, including both abdominal aortic aneurysm and thoracic aortic aneurysm, is
the cause of death of 1% to 2% of the Western population. This review focuses only on …

BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …

BACKGROUND: Knowledge in the aetiopathogeny of aortic disease helps to characterise
aortic lesions better and determine the risk of evolution and therapeutic strategies as well …

Background—Progressive medial degeneration and atrophy is thought to be a cause of
ascending thoracic aortic aneurysms in the elderly. Extensive apoptosis of vascular smooth …

OBJECTIVE: Past studies on the pathogenesis of thoracic aortic aneurysms have, by
concentrating on histological and total tissue analyses, revealed several disease-relevant …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that
promote extracellular matrix destruction and structural weakening. To explore this biology …