J Zhang, N Song, Y Liu, J Guo - Neurochemical Research, 2021 - Springer
Alzheimer's disease (AD) is a common neurodegenerative disease associated with deposition of β-amyloid peptide (Aβ). Platycodin D (PLD), a triterpenesaponin, may possess …
X Jin, MY Liu, DF Zhang, X Zhong, K Du, P Qian… - Pharmacological …, 2019 - Elsevier
abstract Neurodegenerative diseases (NDs) are characterized by the progressive loss of structure and function of neurons most common in elderly population, mainly including …
JT Zhang, LY Xie, Q Shen, W Liu, MH Li, RY Hu… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Alzheimer's disease (AD) was considered to be a neurodegenerative disease that caused cognitive impairment. Reactive Oxidative stress …
Q Gong, Y Wang, X Wang, H Pan, C Yan - Immunobiology, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that has quickly becoming one of the most expensive, lethal, and burdening diseases of this century. In the past twenty years …
C Li, C Zhang, H Zhou, Y Feng, F Tang… - Frontiers in molecular …, 2018 - frontiersin.org
In response to the microenvironment, microglia may polarize into either an M1 pro- inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype …
CY Cao, YX Yang, Z Xie, X Chen, XW Shi, X Yin… - Bioorganic …, 2022 - Elsevier
Emerging evidence suggests the regulation of microglial phenotype balance between M1 and M2 will be a potential therapeutic strategy for microglia-mediated neuroinflammation in …
F Jie, X Yang, B Yang, Y Liu, L Wu, B Lu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Although its pathogenesis remains unclear, studies have indicated microglia-mediated …
B Zhang, YZ Wei, GQ Wang, DD Li, JS Shi… - Frontiers in cellular …, 2019 - frontiersin.org
Neuroinflammation is considered to be an important and inevitable pathological process associated with all types of damages to, and disorders of, the central nervous system. The …
F Han, H Xu, JX Shen, C Pan, ZH Yu, JJ Chen… - Acta Neurobiologiae …, 2020 - ane.pl
Alzheimer's disease (AD) has become the most prevalent neurodegenerative disorder. Given the pathogenesis of AD is unclear, there is currently no drug approved to halt or delay …