Anti‐diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications

X Zhang, Y Zhao, S Chen… - Journal of cachexia …, 2021 - Wiley Online Library
Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has
become a common hallmark of ageing and many chronic diseases. Diabetes mellitus …

The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning

ME Levine, EM Crimmins - Obesity, 2012 - Wiley Online Library
Age associated increases in visceral adiposity and decreases in muscle mass (sarcopenia)
have been shown to contribute to disability in late life. Furthermore, there is evidence that …

Sarcopenia: current perspectives.

DL Waters, RN Baumgartner… - The journal of nutrition …, 2000 - europepmc.org
The development of sarcopenia is a complex multi-factorial process which begins in mid-life
and accelerates after the age of 75 years. Although exercise, nutritional supplementation …

[HTML][HTML] Exploring the impact of obesity on skeletal muscle function in older age

PT Morgan, B Smeuninx, L Breen - Frontiers in Nutrition, 2020 - frontiersin.org
Sarcopenia is of important clinical relevance for loss of independence in older adults. The
prevalence of obesity in combination with sarcopenia ('sarcopenic-obesity') is increasing at …

[HTML][HTML] Pathophysiology and mechanisms of primary sarcopenia

H Nishikawa, S Fukunishi, A Asai… - International …, 2021 - spandidos-publications.com
Aging causes skeletal muscle atrophy, and myofiber loss can be a critical component of this
process. In 1989, Rosenberg emphasized the importance of the loss of skeletal muscle …

Sarcopenia in the elderly: diagnosis, physiopathology and treatment

V Malafarina, F Úriz-Otano, R Iniesta, L Gil-Guerrero - Maturitas, 2012 - Elsevier
Sarcopenia, defined as a syndrome rather than as a pathology, is the loss of muscle mass
and function associated with age. Sarcopenia is an enigma for medicine, and despite the …

Sarcopenia, sarcopenic obesity and mortality in older adults: results from the National Health and Nutrition Examination Survey III

JA Batsis, TA Mackenzie, LK Barre… - European journal of …, 2014 - nature.com
Background: Sarcopenia is defined as the loss of skeletal muscle mass and quality, which
accelerates with aging and is associated with functional decline. Rising obesity prevalence …

Insulin treatment attenuates decline of muscle mass in Japanese patients with type 2 diabetes

R Bouchi, T Fukuda, T Takeuchi, Y Nakano… - Calcified tissue …, 2017 - Springer
Sarcopenia is defined as an age-related loss of skeletal muscle mass and strength, and is a
major cause of disability and mobility limitations. Recent studies have demonstrated that …

Prevalence and risk factors of sarcopenia in patients with diabetes: a meta-analysis

L Feng, Q Gao, K Hu, M Wu, Z Wang… - The Journal of …, 2022 - academic.oup.com
Context The prevalence of sarcopenia in patients with diabetes is 3 times higher than that in
patients without diabetes and is associated with a poor prognosis. Objective To investigate …

The epidemiology of sarcopenia

I Janssen - Clinics in geriatric medicine, 2011 - geriatric.theclinics.com
One of the most dramatic age-related anatomic changes is that which occurs to skeletal
muscle mass. In 1989, Rosenberg 1 coined the term sarcopenia to refer to the age-related …