An overview of tissue-resident memory T cells in the intestine: from physiological functions to pathological mechanisms

Y Lyu, Y Zhou, J Shen - Frontiers in immunology, 2022 - frontiersin.org
The human intestine contains a complex network of innate and adaptive immune cells that
provide protective immunity. The dysfunction of this network may cause various chronic …

Total Recall: Intestinal TRM Cells in Health and Disease

EM Paap, TM Müller, K Sommer, MF Neurath… - Frontiers in …, 2021 - frontiersin.org
Tissue-resident memory T cells (TRM cells) have crucial functions in host defense in
mucosal tissues. They provide local adaptive immune surveillance and allow the fast …

Intestinal CD8+ tissue‐resident memory T cells: From generation to function

L Cheng, S Becattini - European Journal of Immunology, 2022 - Wiley Online Library
Tissue‐resident memory T cells (Trm), and particularly the CD8+ subset, have been shown
to play a pivotal role in protection against infections and tumors. Studies in animal models …

Characteristics of CD8+ and CD4+ Tissue‐Resident Memory Lymphocytes in the Gastrointestinal Tract

P Li, Y Zhang, Y Xu, H Cao, L Li - Advanced Gut & Microbiome …, 2022 - Wiley Online Library
Tissue‐resident memory T cells (TRMs) are plentiful in the memory T cell pool and persist in
barrier sites without recirculating. Increasing evidence has shown that some kinds of CD8+ …

Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis

M Liang, X Wang, D Cai, W Guan, X Shen - Frontiers in Immunology, 2023 - frontiersin.org
Tissue-resident memory T cells (Trm) are a particular type of T cell subgroup, which stably
reside in tissues and have been revealed to be the most abundant memory T cell population …

Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention

N Zhang, MJ Bevan - Immunity, 2013 - cell.com
Tissue-resident memory T (Trm) cells represent a population of memory CD8+ T cells that
can act as first responders to local infection. The mechanisms regulating the formation and …

[HTML][HTML] Human mucosal tissue-resident memory T cells in health and disease

J Lange, O Rivera-Ballesteros, M Buggert - Mucosal immunology, 2022 - Elsevier
Memory T cells are fundamental to maintain immune surveillance of the human body. During
the past decade, it has become apparent that non-recirculating resident memory T cells …

Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

YH Lin, HG Duong, AE Limary, ES Kim, P Hsu… - Immunity, 2023 - cell.com
Tissue-resident memory CD8+ T (T RM) cells are a subset of memory T cells that play a
critical role in limiting early pathogen spread and controlling infection. T RM cells exhibit …

[HTML][HTML] Local inflammatory cues regulate differentiation and persistence of CD8+ tissue-resident memory T cells

T Bergsbaken, MJ Bevan, PJ Fink - Cell reports, 2017 - cell.com
Many pathogens initiate infection at mucosal surfaces, and tissue-resident memory T (Trm)
cells play an important role in protective immunity, yet the tissue-specific signals that …

The Memory T Cell “Communication Web” in Context with Gastrointestinal Disorders—How Memory T Cells Affect Their Surroundings and How They Are Influenced …

A Knauss, M Gabel, MF Neurath, B Weigmann - Cells, 2022 - mdpi.com
Gut-related diseases like ulcerative colitis, Crohn's disease, or colorectal cancer affect
millions of people worldwide. It is an ongoing process finding causes leading to the …