Background Acute kidney injury (AKI) occurs frequently in critically ill patients and is
associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

Acute kidney injury (AKI) promotes an abrupt loss of kidney function that results in
substantial morbidity and mortality. Considerable effort has gone toward identification of …

Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on
damage and reparative processes of tubular epithelial cells. Mechanisms underlying AKI …

Studies in humans and animal models have demonstrated that acute kidney injury (AKI) has
a significant effect on the function of extrarenal organs. The combination of AKI and lung …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Background Single-cell sequencing technologies have advanced our understanding of
kidney biology and disease, but the loss of spatial information in these datasets hinders our …

Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …

Background Understanding the acute kidney injury (AKI) microenvironment changes and the
complex cellular interaction is essential to elucidate the mechanisms and develop new …

Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate and urine
production caused by a number of different diseases. It is associated with renal tissue …