TL Lung, M Saurwein-Teissl, W Parson, D Schönitzer… - Vaccine, 2000 - Elsevier
Dendritic cells (DC) are powerful antigen presenting cells, which have the unique capacity to stimulate naive T cells. In spite of the well-known decline of T cell function in old age, little …
MM Steger, C Maczek… - Clinical & …, 1996 - Wiley Online Library
Dendritic cells are antigen‐presenting cells (APC), which are crucial for the initiation of an immune response. In spite of the well known decline of immune function in old age, no …
M Saurwein-Teissl, N Romani… - Mechanisms of ageing …, 2001 - Elsevier
Dendritic cells (DC) are known as the most efficient antigen-presenting cell type to activate T cells and are key modulators of the immune response. Due to their central role in …
Dendritic cells (DCs) are critical in priming adaptive T-cell responses, but the effects of ageing on interactions between DCs and T cells are unclear. This study investigated the …
SY Tan, LL Cavanagh, W d'Advigor… - Immunology and cell …, 2012 - Wiley Online Library
Aging has profound effects on the immune system, including thymic involution, reduced diversity of the T cell receptor repertoire, reduced effector T cell and B cell function and …
Dendritic cells (DCs) are the single most central player in all immune responses. To assess whether DC alterations may contribute to the immune dysregulation that affects the elderly …
A Agrawal, S Agrawal, S Gupta - Experimental gerontology, 2007 - Elsevier
Dendritic cells (DCs) play a critical role in linking innate and adaptive immunity. A role of DCs in immunosenescence and chronic inflammation associated with aging has not been …
Several age-related alterations occurring in the immune system, especially in T cells and in B cells, may account for an increased susceptibility to infections, autoimmune diseases, and …
S Gupta - Experimental gerontology, 2014 - Elsevier
Aging is associated with a progressive decline in T cell function, chronic inflammation, hyperimmunoglobulinemia, autoimmunity, poor response to vaccines, and increased …