[PDF][PDF] A mouse model of SARS-CoV-2 infection and pathogenesis

SH Sun, Q Chen, HJ Gu, G Yang, YX Wang… - Cell host & …, 2020 - cell.com
Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …

[PDF][PDF] Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

RD Jiang, MQ Liu, Y Chen, C Shan, YW Zhou… - Cell, 2020 - cell.com
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We
previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV …

Cell and animal models of SARS-CoV-2 pathogenesis and immunity

SR Leist, A Schäfer… - Disease models & …, 2020 - journals.biologists.com
The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases
first identified in December 2019, and> 22 million people infected and> 775,000 deaths as …

[PDF][PDF] A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies

AO Hassan, JB Case, ES Winkler, LB Thackray… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …

SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice

ES Winkler, RE Chen, F Alam, S Yildiz, JB Case… - Journal of …, 2022 - Am Soc Microbiol
The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …

[PDF][PDF] Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment

J Sun, Z Zhuang, J Zheng, K Li, RLY Wong, D Liu… - Cell, 2020 - cell.com
Summary COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with> 4,000,000
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …

[HTML][HTML] Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

A Muruato, MN Vu, BA Johnson, ME Davis-Gardner… - PLoS …, 2021 - journals.plos.org
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
resulted in a pandemic causing significant damage to public health and the economy. Efforts …

[HTML][HTML] Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

JW Golden, CR Cline, X Zeng, AR Garrison, BD Carey… - JCI insight, 2020 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …

The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus

W Dong, H Mead, L Tian, JG Park, JI Garcia… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …

[HTML][HTML] Experimental models of COVID-19

LA Caldera-Crespo, MJ Paidas, S Roy… - Frontiers in cellular …, 2022 - frontiersin.org
COVID-19 is the most consequential pandemic of the 21st century. Since the earliest stage
of the 2019-2020 epidemic, animal models have been useful in understanding the …