Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

MY Li, L Li, Y Zhang, XS Wang - Infectious diseases of poverty, 2020 - mednexus.org
Background: Since its discovery in December 2019, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has …

A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome

W Hong, J Yang, Z Bi, C He, H Lei, W Yu… - Signal transduction and …, 2021 - nature.com
The COVID-19 pandemic has covered more than 200 countries and regions around the
world since its outbreak in January 2020. To date, the SARS-CoV-2 virus has caused> 1.2 …

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

R Abdelnabi, R Boudewijns, CS Foo, L Seldeslachts… - …, 2021 - thelancet.com
Background Within one year after its emergence, more than 108 million people acquired
SARS-CoV-2 and almost 2· 4 million succumbed to COVID-19. New SARS-CoV-2 variants of …

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

JP Natekar, H Pathak, S Stone, P Kumari, S Sharma… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current
pandemic, resulting in millions of deaths worldwide. Increasingly contagious variants of …

Of mice and men: the coronavirus MHV and mouse models as a translational approach to understand SARS-CoV-2

RW Koerner, M Majjouti, MAA Alcazar, E Mahabir - Viruses, 2020 - mdpi.com
The fatal acute respiratory coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Since COVID-19 was declared a …

Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection

MW Zhuang, Y Cheng, J Zhang… - Journal of medical …, 2020 - Wiley Online Library
The ongoing outbreak of a new coronavirus (2019‐nCoV, or severe acute respiratory
syndrome coronavirus 2 [SARS‐CoV‐2]) has caused an epidemic of the acute respiratory …

Heterogeneous infectivity and pathogenesis of SARS-CoV-2 variants beta, delta and omicron in transgenic K18-hACE2 and wildtype mice

F Tarrés-Freixas, B Trinité, A Pons-Grífols… - Frontiers in …, 2022 - frontiersin.org
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …

Animal models for COVID-19: advances, gaps and perspectives

C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

X Zou, K Chen, J Zou, P Han, J Hao, Z Han - Frontiers of medicine, 2020 - Springer
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to
SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2) …

Emerging SARS-CoV-2 variants expand species tropism to murines

H Shuai, JFW Chan, TTT Yuen, C Yoon, JC Hu… - …, 2021 - thelancet.com
Background Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-
CoV-2 variants, including B. 1.1. 7, B. 1.351, P. 1, and P. 3, contain mutations in spike that …