The wealth of genomic information currently available to researchers and clinicians has
dramatically changed the way some diseases are defined. However, leveraging this …

Current and emerging biomedical science efforts are driven by determining how to improve
clinical outcomes for patients, but the roadmap to achieve this goal has been controversial …

We implemented a personalized cancer therapy (PCT) program in a clinical setting, applying
an integrative genomics approach to maximally elucidate the complexity of each tumor. For …

Publisher Summary This chapter discusses systems-based approaches to translational
medicine. This is made possible by the convergent acceleration of several disciplines …

The current paper discusses the use of genomics in the context of the changing landscape
of clinical practice and modern medicine. Medical practice has shifted considerably over the …

Background Personalized therapy provides the best outcome of cancer care and its
implementation in the clinic has been greatly facilitated by recent convergence of enormous …

Some cancers are driven by targetable genomic alterations that dysregulate key pathways
influencing cell growth and survival. These tumors lend themselves to significant, although …

Cancer is a heterogeneous disease, originating in different tissues and involving a number
of distinct molecular pathways. With the growing availability of high-throughput biological …

Delivering personalized therapeutic options to cancer patients based on the genetic and
molecular aberrations of the tumor offers great promise to improve the outcomes of cancer …

The availability of targeted anticancer drugs and the relative affordability of genomic
analyses has led to a growing expectation among patients with cancer that they can receive …