Meta-analysis of expression of hepatic organic anion–transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue
J Badée, B Achour, A Rostami-Hodjegan… - Drug Metabolism and …, 2015 - ASPET
Organic anion–transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 transporters
play an important role in hepatic drug disposition. Recently, an increasing number of studies …
play an important role in hepatic drug disposition. Recently, an increasing number of studies …
Quantification of hepatic organic anion transport proteins OAT2 and OAT7 in human liver tissue and primary hepatocytes
A Vildhede, E Kimoto, AD Rodrigues… - Molecular …, 2018 - ACS Publications
Organic anion transporter (OAT) 2 and OAT7 were recently shown to be involved in the
hepatic uptake of drugs; however, there is limited understanding of the population variability …
hepatic uptake of drugs; however, there is limited understanding of the population variability …
Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes
E Kimoto, K Yoshida, LM Balogh, Y Bi… - Molecular …, 2012 - ACS Publications
Since the substrate specificities of OATP1B1, 1B3, and 2B1 are broad and overlapping, the
contribution of each isoform to the overall hepatic uptake is of concern when assessing …
contribution of each isoform to the overall hepatic uptake is of concern when assessing …
Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption
Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …
and are increasingly being recognized as important factors in governing drug and …
Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination
NF Smith, WD Figg, A Sparreboom - Expert opinion on drug …, 2005 - Taylor & Francis
Members of the organic anion transporting polypeptide (OATP) family are responsible for the
cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple …
cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple …
Changes in organic anion transporting polypeptide uptake in HEK293 overexpressing cells in the presence and absence of human plasma
Generating accurate in vitro data is crucial for in vitro to in vivo extrapolation and
pharmacokinetic predictions. The use of human embryonic kidney (HEK) 293 cells …
pharmacokinetic predictions. The use of human embryonic kidney (HEK) 293 cells …
Effect of human plasma on hepatic uptake of organic anion–transporting polypeptide 1B substrates: studies using transfected cells and primary human hepatocytes
Y Bi, S Ryu, DA Tess, AD Rodrigues… - Drug Metabolism and …, 2021 - ASPET
Current challenges with the in vitro–in vivo extrapolation (IVIVE) of hepatic uptake clearance
involving organic anion–transporting polypeptide (OATP) 1B1/1B3 hinder drug design …
involving organic anion–transporting polypeptide (OATP) 1B1/1B3 hinder drug design …
Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion …
Y Nozaki, S Izumi - Drug Metabolism and Pharmacokinetics, 2020 - Elsevier
Hepatic uptake mediated by organic anion transporting polypeptide (OATP) 1B1 and 1B3
can serve as a major elimination pathway for various anionic drugs and as a site of drug …
can serve as a major elimination pathway for various anionic drugs and as a site of drug …
Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems …
C Ji, WR Tschantz, ND Pfeifer, M Ullah… - Analytica chimica …, 2012 - Elsevier
OATP1B1, OATP1B3 and OATP2B1 are important members of the organic anion
transporting polypeptides (OATP) family and are implicated in the hepatic disposition of …
transporting polypeptides (OATP) family and are implicated in the hepatic disposition of …
Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs
T Nakanishi, I Tamai - Drug metabolism and pharmacokinetics, 2012 - jstage.jst.go.jp
There is convincing evidence that many organic anion transporting polypeptide (OATP)
transporters influence the pharmacokinetics and pharmacological efficacy of their substrate …
transporters influence the pharmacokinetics and pharmacological efficacy of their substrate …
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