Background: Transport proteins, for example the drug export pump P-glycoprotein, are
important for the absorption, distribution and excretion of drugs. Inhibition and induction of P …

OATP1B1 (SLCO1B1) is predominantly expressed at the basolateral membrane of
hepatocytes and is critically important for the hepatic uptake and clearance of numerous …

The solute carrier, human organic anion transporting polypeptide 1A2 (OATP1A2, OATP-A,
OATP1 and OATP) is highly expressed in the intestine, kidney, cholangiocytes and the blood …

We generated the organic anion transporting polypeptide (Oatp) 1b2 knockout (KO) mouse
model and assessed its utility to study hepatic uptake using model compounds: cerivastatin …

Organic anion transporting polypeptides (OATP, SLCO genes) mediate the uptake of
endobiotics and drugs. Thus, their expression levels and pattern could be of relevance for …

We cloned and expressed a new organic anion transporting polypeptide (OATP), termed
human OATP2,(OATP-C, LST-1; symbol SLC21A6), involved in the uptake of various …

OATP1B1 and OATP1B3 mediate hepatic uptake of many drugs (eg, statins) and can
mediate transporter-mediated drug-drug-interactions (DDIs). Bortezomib is the first-in-class …

Background: Hepatic uptake of differently charged amphipathic endo-and xenobiotics is
thought to occur via distinct carrier-mediated transport systems. Alternatively, a single rat …

Organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3 are human
hepatocyte transporters that mediate the uptake of various endogenous and exogenous …

The organic anion transporting polypeptide 2B1 (OATP2B1) was one of the first cloned
members of the SLCO family. However, its physiological and pharmacological role is still …