Astroglial S100B Secretion Is Mediated by Ca2+ Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues

MC Leite, F Galland, MC Guerra, L Rodrigues… - International Journal of …, 2023 - mdpi.com
S100B, a homodimeric Ca2+-binding protein, is produced and secreted by astrocytes, and
its extracellular levels have been used as a glial marker in brain damage and …

S100B Secretion in Astrocytes, Unlike C6 Glioma Cells, Is Downregulated by Lactate

NG Selistre, L Rodrigues, BC Federhen, V Gayger-Dias… - Metabolites, 2023 - mdpi.com
S100B is a calcium-binding protein produced and secreted by astrocytes in response to
various extracellular stimuli. C6 glioma cells are a lineage commonly employed for astroglial …

S100B Secretion in Acute Brain Slices: Modulation by Extracellular Levels of Ca2+ and K+

P Nardin, L Tortorelli, A Quincozes-Santos… - Neurochemical …, 2009 - Springer
Hippocampal slices have been widely used to investigate electrophysiological and
metabolic neuronal parameters, as well as parameters of astroglial activity including protein …

S100B expression in and effects on microglia

C Adami, G Sorci, E Blasi, AL Agneletti, F Bistoni… - Glia, 2001 - Wiley Online Library
We evaluated the intracellular and extracellular biological role of S100B protein with respect
to microglia. S100B, which belongs to the multigenic family of Ca2+‐binding proteins, is …

S100B in brain damage and neurodegeneration

M Rothermundt, M Peters, JHM Prehn… - … research and technique, 2003 - Wiley Online Library
S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …

High glutamate decreases S100B secretion stimulated by serum deprivation in astrocytes

D Gonçalves, J Karl, M Leite, L Rotta, C Salbego… - …, 2002 - journals.lww.com
S100B is a calcium-binding protein expressed and secreted by astrocytes, playing a
neurotrophic role in neighboring cells. A protective role of the S100B against glutamate …

S100B in neuropathologic states: the CRP of the brain?

J Sen, A Belli - Journal of neuroscience research, 2007 - Wiley Online Library
In recent years there has been a proliferation of interest in the brain‐specific protein S100B,
its many physiologic roles, and its behaviour in various neuropathologic conditions. Since …

S100B: astrocyte specific protein

N Tateishi, T Shimoda, N Yada… - … Japanese Journal of …, 2006 - europepmc.org
The S100B is a Ca2+ binding proteins of EF-hand type and is produced primarily by
astrocytes in the central nervous system. This protein has been implicated in the Ca2+ …

High glutamate decreases S100B secretion by a mechanism dependent on the glutamate transporter

F Tramontina, MC Leite, D Gonçalves… - Neurochemical …, 2006 - Springer
Several molecules have been shown to be involved in glial-neuronal communication,
including S100B, an astrocyte-derived neurotrophic cytokine. Extracellular S100B protects …

Extracellular S100β disrupts Bergman glia morphology and synaptic transmission in cerebellar Purkinje cells

OS Belozor, DA Yakovleva, IV Potapenko, AN Shuvaev… - Brain Sciences, 2019 - mdpi.com
Astrogliosis is a pathological process that affects the density, morphology, and function of
astrocytes. It is a common feature of brain trauma, autoimmune diseases, and …