Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance …

M Ye, J Chen, F Lu, M Zhao, S Wu, C Hu, P Yu, J Kan… - Cell & Bioscience, 2023 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most abundant
reversible methylation modification in eukaryotes, and it is reportedly closely associated with …

FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells

F Zhao, F Ge, M Xie, Z Li, C Zang, L Kong, Y Pu… - Clinical & Experimental …, 2022 - Springer
Abstract N6-methyladenosine (m6A) is the most prevalent and internal modification that
occurs in the messenger RNAs of eukaryotes. However, knowledge of the impact of these …

N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation

Z Zhang, L Wang, L Zhao, Q Wang… - Clinical and …, 2022 - Wiley Online Library
Background As the most widespread mRNAs modification, N6‐methyladenosine (m6A) is
dynamically and reversibly modulated by methyltransferases and demethylases. ALKBH5 is …

N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1

D Wang, X Qu, W Lu, Y Wang, Y Jin, K Hou… - Frontiers in …, 2021 - frontiersin.org
Abnormal RNA m6A methylation is known to lead to the occurrence and progression of
multiple cancers including gastric cancer (GC). However, the integrative effects of all m6A …

[HTML][HTML] Depletion of the m6A demethylases FTO and ALKBH5 impairs growth and metastatic capacity through EMT phenotype change in clear cell renal cell …

W Hu, N Klümper, D Schmidt, M Ritter… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Background: N 6-methyladenosine (m 6 A) is one of the most common RNA modifications in
eukaryotes and has effects on RNA structure and stability. Recent studies have shown that …

Comprehensive analysis of differentially expressed profiles of mRNA N6-methyladenosine in colorectal cancer

N Li, Q Guo, Q Zhang, BJ Chen, XA Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Aim: To comprehensively profile the landscape of the mRNA N6-methyladenosine (m6A)
modification in human colorectal cancer (CRC). Methods: Methylated RNA …

[HTML][HTML] m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation

J Li, L Zhu, Y Shi, J Liu, L Lin… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) acts as the most common mRNA modification in
mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified …

Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α

Z Yang, Y Quan, Y Chen, Y Huang, R Huang… - … and Targeted Therapy, 2021 - nature.com
Colorectal cancer (CRC) is an important digestive tract tumor with high malignancy. Nearly
one million people suffer from CRC every year with a mortality rate of 33%. Therefore, it is …

m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling

X Liu, H He, F Zhang, X Hu, F Bi, K Li, H Yu… - Cell death & …, 2022 - nature.com
Exploring the epigenetic regulation mechanism of colorectal cancer (CRC) from the
perspective of N6-methyladenosine (m6A) modification may provide a new target for tumor …

m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer

X Duan, L Yang, L Wang, Q Liu, K Zhang, S Liu, C Liu… - Cell & bioscience, 2022 - Springer
Background Epitranscriptomics studies have contributed greatly to the development of
research on human cancers. In recent years, N6-methyladenosine (m6A), an RNA …