Temperature variations in cells, tissues and organs may occur in a number of circumstances.
We report here that reducing temperature of cells in culture to 25° C for 5 days followed by a …

Since its discovery in 1962 by Ritossa, the heat shock response has been extensively
studied by a number of investigators to understand the molecular mechanism underlying the …

Mammalian cells cultured in vitro are able to recover from cold stress. However, the
mechanisms activated during cold stress and recovery are still being determined. We here …

Hyperthermia is a promising anticancer treatment used in combination with radiotherapy
and chemotherapy. Temperatures above 41.5° C are cytotoxic and hyperthermia treatments …

When exposed to environmental stress, cell survival is supported by the upregulation of
stress proteins such as heat shock proteins (HSPs) or glucose regulated proteins (GRPs) …

Cells respond to adverse environmental conditions by expressing heat shock proteins,
which serve to protect cells from harmful effects of the stress conditions. In this study we …

Protein homeostasis or proteostasis, the correct balance between production and
degradation of proteins, is an essential pillar for proper cellular function. Among the several …

Oxidative stress is one of the major causes of cellular injury. Various reactive oxygen (ROS)
and nitrogen (RNS) species such as superoxide, hydroxyl radical, peroxynitrite, and nitric …

Abstract Hyperthermia (39–45° C) has emerged as an alternate prospect for cancer therapy
in combination with radiation and chemotherapy. Despite promising progress in the clinic …

This review was undertaken to identify responses of mammalian cells to cold temperatures,
such as might be encountered in therapeutic procedures where body temperatures are …