Therapy for early COVID-19: a critical need

PS Kim, SW Read, AS Fauci - Jama, 2020 - jamanetwork.com
While coronavirus disease 2019 (COVID-19) is predominantly self-limited, up to 20% of
symptomatic individuals will progress to severe or critical disease with clinical …

Treating COVID-19—off-label drug use, compassionate use, and randomized clinical trials during pandemics

AC Kalil - Jama, 2020 - jamanetwork.com
In the 2014 Ebola outbreak, close to 30 000 individuals developed Ebola viral disease
(EVD), and numerous therapies were tested against this virus, including chloroquine …

Finding effective treatments for COVID-19: scientific integrity and public confidence in a time of crisis

JL Goodman, L Borio - Jama, 2020 - jamanetwork.com
Everyone wants new treatments and vaccines to address the devastation of coronavirus
disease 2019 (COVID-19). But, currently, under intense pressure and based on hope and …

The first 2 years of COVID-19: lessons to improve preparedness for the next pandemic

JB Nuzzo, LO Gostin - JAMA, 2022 - jamanetwork.com
(WHO) CountryOfficeinChinareportednovel “viralpneumonias of unknown cause” in Wuhan,
but China did not confirm case clusters until January 3, 2020. Two years later, more than …

COVID-19—new insights on a rapidly changing epidemic

C Del Rio, PN Malani - Jama, 2020 - jamanetwork.com
Since first reported in Wuhan, China, in late December 2019, the outbreak of the novel
coronavirus now known as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) …

Precision therapeutic targets for COVID-19

ZA Krumm, GM Lloyd, CP Francis, LH Nasif… - Virology journal, 2021 - Springer
Beginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19). SARS …

Coronavirus disease 2019 treatment: a review of early and emerging options

EK McCreary, JM Pogue - Open forum infectious diseases, 2020 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus
disease 2019 (COVID-19), has spread across the globe resulting in a pandemic. At the time …

Recovery from severe COVID-19: leveraging the lessons of survival from sepsis

HC Prescott, TD Girard - Jama, 2020 - jamanetwork.com
As of July 30, 2020, more than 17 million people worldwide have been diagnosed with
coronavirus disease 2019 (COVID-19), and more than 665 000 have died. In many …

Treatment of COVID-19: old tricks for new challenges

AC Cunningham, HP Goh, D Koh - Critical Care, 2020 - Springer
Coronavirus disease (COVID-19), which appeared in December 2019, presents a global
challenge, particularly in the rapid increase of critically ill patients with pneumonia and …

Long COVID: a primer for family physicians

T Greenhalgh, M Knight - American family physician, 2020 - aafp.org
As the United States struggles with a prolonged wave of acute coronavirus disease 2019
(COVID-19; see article recently published in American Family Physician), family physicians …